CNRS UMR6247, INSERM U931, Génétique Reproduction et Développement, Clermont Université, Aubière, France.
Mol Cell Endocrinol. 2012 Mar 31;351(1):28-36. doi: 10.1016/j.mce.2011.10.006. Epub 2011 Oct 15.
In the last 10 years, extensive studies showed that the cAMP pathway is deregulated in patients suffering from adrenocortical tumours, and particularly in primary pigmented nodular adrenocortical disease (PPNAD). Here we describe how evidence arising from the analysis of patients' data, mouse models and in vitro experiments, have shed light on the cAMP pathway as a central player in adrenal physiopathology. We also show how novel data generated from mouse models may point to new targets for potential therapies.
在过去的 10 年中，大量研究表明，cAMP 通路在患有肾上腺皮质肿瘤的患者中失调，特别是在原发性色素性结节性肾上腺皮质疾病（PPNAD）中。在这里，我们描述了从患者数据分析、小鼠模型和体外实验中获得的证据如何揭示 cAMP 通路作为肾上腺病理生理学的核心参与者。我们还展示了从小鼠模型中获得的新数据如何可能指向潜在治疗的新靶点。
