苯二氮䓬类药物的使用与痴呆风险：来自卡菲利前瞻性研究（CaPS）的证据。
Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS).
机构信息
Department of Primary Care and Public Health, Cardiff University, Cardiff, UK.
出版信息
J Epidemiol Community Health. 2012 Oct;66(10):869-73. doi: 10.1136/jech-2011-200314. Epub 2011 Oct 27.
BACKGROUND
Benzodiazepine use is widespread in older people, although its benefit is uncertain.
AIM
To investigate the long-term effect of benzodiazepine use upon dementia risk.
METHODS
A prospective cohort of men seen on five occasions over 22 years with full medication histories, repeat measures of cognitive function and a clinical diagnosis of dementia.
RESULTS
Of 1134 men with complete data, 103 (9.1%) had been taking benzodiazepines regularly at one or more phases. These men showed a marked increased incidence of dementia (OR=3.50, 95% CI 1.57 to 7.79, p=0.002), which persisted despite adjustment for psychological distress and other covariates. Men exposed in earlier phases showed a greater association than more recent exposure, counter to what one would expect if this was due to reverse causation, though we failed to demonstrate a dose-response effect with drug duration.
CONCLUSION
The taking of benzodiazepines is associated with an increased risk of dementia.
背景
苯二氮䓬类药物在老年人中广泛使用，但其益处尚不确定。
目的
研究苯二氮䓬类药物使用与痴呆风险的长期关系。
方法
一项前瞻性队列研究，纳入了在 22 年内接受了 5 次随访的男性，这些男性有完整的用药史、认知功能的重复测量以及痴呆的临床诊断。
结果
在有完整数据的 1134 名男性中，有 103 名（9.1%）在一个或多个阶段定期服用苯二氮䓬类药物。这些男性的痴呆发病率明显增加（OR=3.50，95%CI 1.57 至 7.79，p=0.002），尽管调整了心理困扰和其他协变量，但这种情况仍然存在。与预期的相反，如果这是由于反向因果关系引起的，那么早期暴露的男性比最近暴露的男性表现出更强的相关性，尽管我们未能证明药物持续时间与剂量反应之间存在关系。
结论
服用苯二氮䓬类药物与痴呆风险增加有关。
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