白细胞介素-2 在念珠菌性阴茎头炎中的表达及其临床意义。

Expression of interleukin-2 in Candidal balanoposthitis and its clinical significance.

机构信息

Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.

出版信息

Chin Med J (Engl). 2011 Sep;124(17):2776-8.

PMID:22040441

Abstract

BACKGROUND

Candidal balanoposthitis (CB) is a common male genital infection. Autoimmune mechanisms may play an important role in the pathogenesis of CB. Interleukin-2 (IL-2) is an important molecule in cell-mediated immunity.

METHODS

One hundred and one patients were diagnosed with CB using mycology culture in the dermatology and urology clinics in our hospital. Ninety-four healthy males were randomly selected as controls. We studied serum levels of IL-2 of patients with CB using ELISA and analyzed the correlations between serum IL-2 and clinical data.

RESULTS

Serum IL-2 concentrations in CB patients were significantly lower than that in the control group ((7.80 ± 4.78) vs. (15.44 ± 7.90) ng/L; t = 2.27, P < 0.05). The incidence of CB in the low-level group was significantly higher than that in the high-level group (70% (71/101) vs. 36% (30/84), P < 0.05). Low levels of serum IL-2, comorbidity with other sexually transmitted diseases (STDs), and sexual partners with vulvovaginal candidiasis (VVC) increased the risk of CB.

CONCLUSION

The pathogenesis of CB is a complex procedure that includes internal autoimmune factors.

摘要

背景

白色念珠菌性包皮龟头炎（CB）是一种常见的男性生殖器感染。自身免疫机制可能在 CB 的发病机制中起重要作用。白细胞介素-2（IL-2）是细胞介导免疫中的重要分子。

方法

在我院皮肤科和泌尿科诊所，通过真菌培养诊断了 101 例 CB 患者。随机选择 94 名健康男性作为对照。我们使用 ELISA 研究了 CB 患者的血清 IL-2 水平，并分析了血清 IL-2 与临床数据之间的相关性。

结果

CB 患者的血清 IL-2 浓度明显低于对照组（（7.80 ± 4.78）vs.（15.44 ± 7.90）ng/L；t = 2.27，P < 0.05）。低水平组 CB 的发生率明显高于高水平组（70%（71/101）vs. 36%（30/84），P < 0.05）。低水平的血清 IL-2、合并其他性传播疾病（STDs）和性伴侣患有外阴阴道念珠菌病（VVC）增加了 CB 的风险。