两亲性星型嵌段共聚物和纳米胶束的超分子转变为纳米囊泡。

Amphiphilic star-block copolymers and supramolecular transformation of nanogel-like micelles to nanovesicles.

机构信息

Department of Bioengineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore.

出版信息

Chem Commun (Camb). 2011 Dec 28;47(48):12849-51. doi: 10.1039/c1cc15965h. Epub 2011 Nov 2.

DOI:10.1039/c1cc15965h

PMID:22045432

Abstract

Amphiphilic star-block copolymers based on poly(3-hydroxybutyrate) with adamantyl end-functionalization were synthesized via anionic ring-opening polymerization and alkyne-azide "Click Chemistry" coupling. In aqueous medium, the copolymers self-assembled into nanogel-like large compound micelles, and transformed into vesicular nanostructures under the direction of host-guest interaction between the adamantyl end and dimethyl-β-cyclodextrin.

摘要

基于 3-羟基丁酸酯的具有金刚烷基末端官能化的两亲性星型嵌段共聚物通过阴离子开环聚合和炔基-叠氮化物“点击化学”偶联反应合成。在水介质中，共聚物自组装成纳米凝胶状大复合胶束，在金刚烷基末端与二甲基-β-环糊精之间的主客体相互作用的指导下，转变为囊泡状纳米结构。