Blask D E, Leadem C A, Pelletier D B
Department of Anatomy, University of Arizona, College of Medicine, Tucson.
J Neural Transm Gen Sect. 1990;82(1):1-9. doi: 10.1007/BF01244830.
The effects of MSG on PRL cell activity in hamsters was assessed by injecting either MSG (8 mg/g body weight) or saline into male and female hamsters on day 8 of the neonatal period. One-hundred and three days later, the anterior pituitaries were removed for the analysis of PRL synthesis and storage. Serum PRL levels were also determined by radioimmunoassay as an index of in vivo PRL secretion. Blood levels of PRL were decreased by 74% in female and 88% in male hamsters treated with MSG as compared with vehicle controls. In females, glutamate induced a drop in PRL storage (90%) and synthesis (82%) while in male animals glutamate caused a non-significant decrease in PRL storage (48%) and synthesis (31%) as compared with controls. These results indicate that MSG-induced arcuate nucleus lesions inhibit PRL cell activity in the hamster.
通过在新生期第8天给雄性和雌性仓鼠注射味精（8毫克/克体重）或生理盐水，评估味精对仓鼠催乳素（PRL）细胞活性的影响。103天后，取出垂体前叶用于分析PRL的合成和储存。血清PRL水平也通过放射免疫测定法测定，作为体内PRL分泌的指标。与载体对照相比，用味精处理的雌性仓鼠的PRL血液水平降低了74%，雄性仓鼠降低了88%。在雌性中，谷氨酸导致PRL储存（90%）和合成（82%）下降，而在雄性动物中，与对照组相比，谷氨酸导致PRL储存（48%）和合成（31%）无显著下降。这些结果表明，味精诱导的弓状核损伤抑制了仓鼠PRL细胞的活性。
