Psychology Department, Rice University, Houston, TX 77005, USA.
Cogn Neuropsychol. 2010 Dec;27(8):614-35. doi: 10.1080/02643294.2011.609541.
Patients with "refractory access dysphasia" have been a source of unique insight into the organization of previously unexplored domains of semantic knowledge (i.e., proper nouns, geography, concrete and abstract concepts). However, much of the relevant data have been based on the performance of a small number of patients. Here, we present 2 patients who both display a "refractory access" pattern of performance on spoken-word-written-word matching tasks and test their performance in the domains of famous people, geography, and abstract and concrete words. While these patients show performance similar to that for the previously reported patients in the domains of famous people and geography, they show a very different pattern of performance with abstract and concrete nouns. We discuss possible reasons why patients may differ in performance and evidence for and against the "differential frameworks" hypothesis for the organization of concrete and abstract concepts.
患有“难治性通道性构音障碍”的患者为以前未探索的语义知识领域（即专有名词、地理、具体和抽象概念）的组织提供了独特的见解。然而，大量相关数据都基于少数患者的表现。在这里，我们介绍了 2 名患者，他们在口语-书面语匹配任务中的表现都呈现出“难治性通道”模式，并测试了他们在名人、地理和抽象和具体词汇领域的表现。虽然这些患者在名人领域和地理领域的表现与之前报道的患者相似，但他们在抽象和具体名词方面的表现却呈现出非常不同的模式。我们讨论了患者在表现上可能存在差异的原因，以及支持和反对具体和抽象概念组织的“差异化框架”假说的证据。
