Suppr超能文献

新型氨基酸衍生物的合成及抗结核活性。

Synthesis and antitubercular activity of novel amino acid derivatives.

机构信息

Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100 Manguinhos, 21041-250 Rio de Janeiro, RJ, Brazil.

出版信息

Chem Biol Drug Des. 2012 Feb;79(2):216-22. doi: 10.1111/j.1747-0285.2011.01269.x. Epub 2012 Jan 4.

DOI:10.1111/j.1747-0285.2011.01269.x
PMID:22078007
Abstract

In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9a-d, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50 μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20 μg/mL).

摘要

在这项工作中，评估了 17 种新的氨基酸 N-酰腙衍生物对结核分枝杆菌 H37Rv 的体外抗菌活性。化合物 8b、8e、8f、9a-d 和 10c 的最小抑菌浓度活性在 12.5 至 50μg/mL 之间，可与分枝杆菌抑制药物 D-环丝氨酸（20μg/mL）相媲美。

相似文献

1
Synthesis and antitubercular activity of novel amino acid derivatives.
Chem Biol Drug Des. 2012 Feb;79(2):216-22. doi: 10.1111/j.1747-0285.2011.01269.x. Epub 2012 Jan 4.
2
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives.
Med Chem. 2011 Nov;7(6):611-23. doi: 10.2174/157340611797928325.
3
Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones.
Bioorg Med Chem Lett. 2011 May 15;21(10):2866-8. doi: 10.1016/j.bmcl.2011.03.082. Epub 2011 Mar 30.
4
Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity.
Eur J Med Chem. 2006 Nov;41(11):1253-61. doi: 10.1016/j.ejmech.2006.06.009. Epub 2006 Aug 17.
5
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.
Bioorg Med Chem. 2009 Aug 15;17(16):6063-72. doi: 10.1016/j.bmc.2009.06.051. Epub 2009 Jun 27.
6
Synthesis and in vitro antitubercular activity of a series of quinoline derivatives.
Bioorg Med Chem. 2009 Feb 15;17(4):1474-80. doi: 10.1016/j.bmc.2009.01.013. Epub 2009 Jan 15.
7
Synthesis and antitubercular activities of substituted benzoic acid N'-(substituted benzylidene/furan-2-ylmethylene)-N-(pyridine-3-carbonyl)-hydrazides.
Eur J Med Chem. 2010 Dec;45(12):6085-9. doi: 10.1016/j.ejmech.2010.08.030. Epub 2010 Aug 18.
8
Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives.
Eur J Med Chem. 2008 May;43(5):981-5. doi: 10.1016/j.ejmech.2007.07.001. Epub 2007 Jul 15.
9
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives.
Eur J Med Chem. 2011 Mar;46(3):974-8. doi: 10.1016/j.ejmech.2011.01.004. Epub 2011 Jan 13.
10
Synthesis and in vitro antitubercular activity of some 1-[(4-sub)phenyl]-3-(4-{1-[(pyridine-4-carbonyl)hydrazono]ethyl}phenyl)thiourea.
Bioorg Med Chem Lett. 2006 Feb 15;16(4):876-8. doi: 10.1016/j.bmcl.2005.11.004. Epub 2005 Nov 21.

引用本文的文献

1
Unveiling the active isomer of cycloalanopine, a cyclic opine from LS8, through synthesis and analog production.
RSC Med Chem. 2020 Apr 6;11(4):528-531. doi: 10.1039/d0md00033g. eCollection 2020 Apr 1.
2
Design and activity study of a melittin-thanatin hybrid peptide.
AMB Express. 2019 Jan 30;9(1):14. doi: 10.1186/s13568-019-0739-z.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验