Krick Erika L, Moore Reneé H, Cohen Rachel B, Sorenmo Karin U
Department of Clinical Studies, Matthew J Ryan Veterinary Hospital of the University of Pennsylvania, PA 19104, USA.
J Feline Med Surg. 2011 Dec;13(12):976-83. doi: 10.1016/j.jfms.2011.08.002. Epub 2011 Nov 9.
The study purpose was to determine the prognostic significance of weight changes during feline lymphoma treatment. A secondary purpose was to compare weight changes according to baseline body weight, cell type and location. Records of 209 cats treated for lymphoma with chemotherapy from 1995 to 2007 were evaluated. Signalment, cell type, lymphoma location, baseline body weight, weight during treatment, and outcome information were collected. Lymphoma specific survival (LSS) was compared according to baseline weight and weight changes during treatment. Weight change over time was compared according to cell type (small versus large), location (gastrointestinal versus non-gastrointestinal) and baseline weight. Cats with large cell lymphoma that lost ≥ 5% body weight at 1 month had significantly shorter LSS than those that gained or had stable weight (P = 0.004). Percentage weight change over time differed significantly according to baseline weight group. These findings demonstrate the prognostic importance of weight loss in feline large cell lymphoma.
本研究的目的是确定猫淋巴瘤治疗期间体重变化的预后意义。次要目的是根据基线体重、细胞类型和部位比较体重变化。对1995年至2007年接受化疗治疗淋巴瘤的209只猫的记录进行了评估。收集了信号、细胞类型、淋巴瘤部位、基线体重、治疗期间体重和结局信息。根据基线体重和治疗期间的体重变化比较淋巴瘤特异性生存期（LSS）。根据细胞类型（小细胞与大细胞）、部位（胃肠道与非胃肠道）和基线体重比较随时间的体重变化。大细胞淋巴瘤猫在1个月时体重减轻≥5%的LSS明显短于体重增加或体重稳定的猫（P = 0.004）。随时间的体重变化百分比根据基线体重组有显著差异。这些发现证明了体重减轻在猫大细胞淋巴瘤中的预后重要性。
