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长期护理机构中抗菌谱的制定。

Development of an antibiogram in a long-term care facility.

作者信息

Phillippe Haley M, Darling Charles H, Aikens Garrett B, Wargo Kurt A

机构信息

Auburn University Harrison School of Pharmacy, Huntsville, Alabama 35801, USA.

出版信息

Consult Pharm. 2011 Nov;26(11):829-36. doi: 10.4140/TCP.n.2011.829.

Abstract

OBJECTIVE

To create an antibiogram-a profile of an organism's susceptibility/resistance to a panel of antibiotics- for a long-term care facility to assess the prevalence of resistance of bacteria present at the facility.

DESIGN

Retrospective analysis of culture and sensitivity data from July 1, 2009, through June 30, 2010.

SETTING

A long-term care facility in Huntsville, Alabama.

PATIENTS AND PARTICIPANTS

Residents of the long-term care facility that had one or more culture and sensitivity test performed.

MAIN OUTCOME MEASURE

Susceptibility of bacteria to each antimicrobial tested.

RESULTS

Results were compiled and reported according to the Clinical and Laboratory Standards Institute Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data. The most commonly seen bacteria in our long-term care facility were Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus mirabilis. Resistance rates for these bacteria were high and included the presence of methicillinresistant S. aureus and extended-spectrum beta-lactamase-producing bacteria.

CONCLUSION

Resistance rates were high among all organisms reported. This poses a serious threat to the health care team's ability to effectively treat residents of this facility. Development of an antibiogram to assist physicians in antimicrobial selection will be beneficial in helping evaluate trends in drug resistance to current available treatments. Implementing clinical pathways for empiric treatment of infections could improve the ability to provide consistent treatment for all residents in the facility.

摘要

目的

为一家长期护理机构创建一份抗菌谱——即一种生物体对一组抗生素的敏感性/耐药性概况——以评估该机构中存在的细菌耐药性流行情况。

设计

对2009年7月1日至2010年6月30日期间的培养和药敏数据进行回顾性分析。

地点

阿拉巴马州亨茨维尔的一家长期护理机构。

患者和参与者

接受过一次或多次培养和药敏试验的长期护理机构居民。

主要观察指标

细菌对每种测试抗菌药物的敏感性。

结果

根据临床和实验室标准协会《累积抗菌药物敏感性试验数据的分析和报告》对结果进行汇总和报告。我们长期护理机构中最常见的细菌是大肠杆菌、金黄色葡萄球菌、粪肠球菌、肺炎克雷伯菌、铜绿假单胞菌和奇异变形杆菌。这些细菌的耐药率很高,包括耐甲氧西林金黄色葡萄球菌和产超广谱β-内酰胺酶细菌的存在。

结论

所有报告的生物体耐药率都很高。这对医疗团队有效治疗该机构居民的能力构成了严重威胁。制定抗菌谱以协助医生选择抗菌药物,将有助于评估对当前可用治疗方法的耐药趋势。实施感染经验性治疗的临床路径可以提高为该机构所有居民提供一致治疗的能力。

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