新型（E）-1-（4-甲基-2-（烷基氨基）噻唑-5-基）-3-芳基丙烯-1-酮类化合物作为有效的抗菌剂。
Novel (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones as potent antimicrobial agents.
机构信息
Aristotle University, School of Pharmacy, Thessaloniki 54124, Greece.
出版信息
Bioorg Med Chem. 2011 Dec 15;19(24):7349-56. doi: 10.1016/j.bmc.2011.10.059. Epub 2011 Oct 25.
New (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones, unsubstituted or carrying fluoro, bromo, methoxy, nitro, methyl and chloro groups on the benzene ring, were synthesized and assayed in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria and fungi. The compounds were very potent towards all tested microorganisms and in most cases their activity was better than that of reference drugs.
新型（E）-1-（4-甲基-2-（烷基氨基）噻唑-5-基）-3-芳基丙烯-2-酮，苯环上无取代基或带有氟、溴、甲氧基、硝基、甲基和氯取代基，被合成并在体外检测其对革兰氏阳性和革兰氏阴性细菌和真菌的抗菌活性。这些化合物对所有测试的微生物都非常有效，在大多数情况下，它们的活性优于参考药物。
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