Tateishi M, Ishida T, Mitsudomi T, Kaneko S, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cancer Res. 1990 Nov 1;50(21):7077-80.
We immunohistochemically examined 131 primary human lung adenocarcinomas for the possible presence of autocrine factors. Transforming growth factor alpha (TGF alpha) and epidermal growth factor (EGF) were considered growth factors with epidermal growth factor receptor (EGFR) as the receptor. Of these tumors, 87 (66%) showed a high expression of TGF alpha, 66 (50%) showed a high expression of EGF, and 55 (42%) were positive for EGFR reactivity. In the EGFR-positive cases, the 5-year survival rates of patients with high TGF alpha and low TGF alpha were 36% and 85%, respectively (P less than 0.05). The 5-year survival rates of patients with high EGF and low EGF were 25% and 77%, respectively (P less than 0.05). In contrast, in the EGFR-negative cases, there was no statistical difference between the 5-year survival rates of patients with either high TGF alpha or EGF and low TGF alpha or EGF. Because autocrine growth mechanisms are present in adenocarcinoma of the human lung, these events may contribute to clarification of tumor development, and perhaps even to a better prognosis.
我们采用免疫组织化学方法检测了131例原发性人肺腺癌中自分泌因子的可能存在情况。转化生长因子α（TGFα）和表皮生长因子（EGF）被认为是以表皮生长因子受体（EGFR）为受体的生长因子。在这些肿瘤中，87例（66%）显示TGFα高表达，66例（50%）显示EGF高表达，55例（42%）EGFR反应呈阳性。在EGFR阳性病例中，TGFα高表达和低表达患者的5年生存率分别为36%和85%（P<0.05）。EGF高表达和低表达患者的5年生存率分别为25%和77%（P<0.05）。相比之下，在EGFR阴性病例中，TGFα或EGF高表达与低表达患者的5年生存率之间无统计学差异。由于人肺腺癌中存在自分泌生长机制，这些情况可能有助于阐明肿瘤的发展，甚至可能有助于改善预后。
