Lepers J P, Fontenille D, Andriamangatiana-Rason M D, Deloron P, Coulanges P
Unité de Recherche sur le Paludisme, Institut Pasteur de Madagascar, Tananarive.
Bull Soc Pathol Exot. 1990;83(3):330-41.
The new epidemic of malaria which spread on the Madagascar high plateau in 1986-1987 is due to the combination of several factors (some of which are analysed by the authors, especially those related to anopheles, parasite and man). The authors compare the situations on the high Plateau and on St Mary Island, on the East Madagascar Coast, where the malaria is stable. Concerning the vector, the most interesting fact is the come-back of Anopheles funestus on the high Plateau from which it had disappeared at the beginning of the fifties. In this area, An.arabiensis seems to be the only representative of the gambiae complex whereas it is An. gambiae s.s. in St Mary Island. The parasite is getting more and more resistant to chloroquine. Nevertheless, man seems to develop protection, but it is difficult to analyse the markers which would prove the protection. However, that protection was assessed, on the humoral and cellular level, against the peptides of the RESA (Ring Infected Erythrocytes Surface Antigen), the circumsporozoite protein and the antigen E.
1986 - 1987年在马达加斯加高原蔓延的新型疟疾疫情是由多种因素共同作用导致的（作者对其中一些因素进行了分析，特别是与按蚊、寄生虫和人类相关的因素）。作者比较了高原地区和马达加斯加东海岸圣玛丽岛的情况，后者疟疾疫情较为稳定。关于病媒，最有意思的是高原地区出现了曾在五十年代初消失的恶疟按蚊。在该地区，阿拉伯按蚊似乎是冈比亚按蚊复合体的唯一代表，而在圣玛丽岛则是冈比亚按蚊指名亚种。寄生虫对氯喹的耐药性越来越强。然而，人类似乎在产生抵抗力，但很难分析出能证明这种抵抗力的标志物。不过，已在体液和细胞水平上评估了针对红细胞表面抗原（RESA）肽、环子孢子蛋白和抗原E的抵抗力。
