通过MDM2基因荧光原位杂交支持诊断为去分化脂肪肉瘤的巨大腹膜后黏液性肿瘤

Giant Retroperitoneal Mucinous Tumor Supportively Diagnosed as a Dedifferentiated Liposarcoma by Fluorescence In Situ Hybridization of MDM2 Gene.

作者信息

Naiki Taku, Hamamoto Shuzo, Kawai Noriyasu, Naiki-Ito Aya, Kojima Yoshiyuki, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro

机构信息

Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Mizuho-ku 467-8601, Nagoya, Japan.

出版信息

ISRN Urol. 2011;2011:261735. doi: 10.5402/2011/261735. Epub 2011 Jun 16.

DOI:10.5402/2011/261735

PMID:22084793

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3195365/

Abstract

Surgical resection was performed on a 47-year-old woman for a retroperitoneal mass that weighed 8.5 kg. Histological examination revealed a myxoid sarcomatous tumor. Because diagnosis could not be determined by immunohistochemistry, attention was focused on MDM2 (murine double minute) gene amplification by fluorescence in situ hybridization (FISH) analysis. The tumor was finally determined to be a dedifferentiated liposarcoma. We experienced a case of a giant retroperitoneal dedifferentiated liposarcoma. FISH analysis was useful for the diagnosis and determination of the therapeutic strategy.

摘要

对一名47岁女性的一个重达8.5千克的腹膜后肿块进行了手术切除。组织学检查显示为黏液样肉瘤性肿瘤。由于免疫组织化学无法确定诊断，因此通过荧光原位杂交（FISH）分析将注意力集中在MDM2（小鼠双微体）基因扩增上。该肿瘤最终被确定为去分化脂肪肉瘤。我们遇到了一例巨大的腹膜后去分化脂肪肉瘤病例。FISH分析对诊断和治疗策略的确定很有用。