初级体感皮层经颅磁刺激调节手部触觉感知。
Continuous theta-burst rTMS over primary somatosensory cortex modulates tactile perception on the hand.
机构信息
Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
出版信息
Clin Neurophysiol. 2012 Jun;123(6):1226-33. doi: 10.1016/j.clinph.2011.09.026. Epub 2011 Nov 18.
OBJECTIVE
Theta-burst stimulation (TBS) over the primary somatosensory cortex (SI) alters cortical excitability, and in its intermittent form (iTBS) improves tactile spatial acuity. The effects of continuous TBS (cTBS) on tactile acuity remain unknown. The present study examined the influence of cTBS over SI on temporal and spatial tactile acuity on the contralateral hand.
METHODS
In separate experiments, temporal discrimination threshold (TDT) and spatial amplitude discrimination threshold (SDT) were obtained from the right hand before and for up to 34 min following real and sham cTBS (600 pulses) over left-hemisphere SI.
RESULTS
CTBS reduced temporal and spatial tactile acuity for up to 18 min following real cTBS. Tactile acuity was unaltered in the groups receiving sham cTBS.
CONCLUSIONS
CTBS over SI impairs both temporal and spatial domains of tactile acuity for a similar duration.
SIGNIFICANCE
CTBS over SI appears to decrease neural activity within targeted cortex and has potential utility in reducing excessive sensory processing.
目的
经体感皮层（SI）theta 爆发刺激（TBS）可改变皮质兴奋性，其间歇性形式（iTBS）可提高触觉空间分辨力。持续 TBS（cTBS）对触觉分辨力的影响尚不清楚。本研究探讨了 cTBS 对 SI 的影响对优势手的时间和空间触觉分辨力的影响。
方法
在单独的实验中，在左半球 SI 进行真实和假 cTBS（600 脉冲）之前和之后长达 34 分钟，从右手获得时间辨别阈值（TDT）和空间幅度辨别阈值（SDT）。
结果
cTBS 可降低真实 cTBS 后长达 18 分钟的时间和空间触觉分辨力。接受假 cTBS 的组中触觉分辨力没有改变。
结论
SI 上的 cTBS 会在相似的时间内损害触觉的时间和空间两个领域的分辨力。
意义
SI 上的 cTBS 似乎降低了目标皮层内的神经活动，并且在减少过度的感觉处理方面具有潜在的效用。
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