Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Biochem Soc Trans. 2011 Dec;39(6):1705-9. doi: 10.1042/BST20110603.
In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact directly with heterochromatin, which implicates the nuclear lamina in a mechanism of specific gene retention at the nuclear periphery and release to the nuclear interior upon gene activation. We also discuss recent data showing that mutations in lamin proteins affect gene positioning and expression, providing a potential mechanism for how these mutations lead to tissue-specific diseases.
在后生动物细胞中,异染色质通常位于核周,而活跃的基因则优先存在于核内。在本文中,我们综述了目前的证据,表明核纤层的成分直接与异染色质相互作用,这表明核纤层在特定基因保留在核周并在基因激活时释放到核内的机制中起作用。我们还讨论了最近的数据,表明核纤层蛋白的突变会影响基因的定位和表达,为这些突变如何导致组织特异性疾病提供了一种潜在的机制。