Department of Experimental Medicine, Pharmacology Division, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy.
Curr Opin Pharmacol. 2012 Feb;12(1):9-17. doi: 10.1016/j.coph.2011.10.022. Epub 2011 Nov 20.
Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the peripheral and central nervous system. TRPV1 is both activated and sensitized by inflammatory endogenous mediators during inflammatory pain conditions and appears to be up regulated in neuropathic pain conditions. Owing to its role as pain integrator, its widespread expression in pain neuraxis and its involvement in pain development TRPV1 offers an exciting opportunity for therapeutic interventions in pain management. In particular, its supraspinal expression within the antinociceptive descending pathway, which includes periaqueductal grey (PAG) and rostral ventromedial medulla (RVM), represents an endogenous switch for extinguishing pain in pathological conditions.
瞬时受体电位香草酸型 1 通道（TRPV1）是一种配体门控阳离子通道，作为一种多模式伤害感受器，广泛表达于外周和中枢神经系统的疼痛传递/调制区域。在炎症性疼痛条件下，炎症内源性介质既能激活 TRPV1 也能使其致敏，并且 TRPV1 在神经病理性疼痛条件下似乎上调。由于 TRPV1 作为疼痛整合器的作用，其在疼痛神经轴中的广泛表达及其在疼痛发展中的参与，为疼痛管理中的治疗干预提供了一个令人兴奋的机会。特别是，其在抗伤害性下行通路中的中枢表达，包括导水管周围灰质（periaqueductal grey，PAG）和延髓头端腹内侧区（rostral ventromedial medulla，RVM），代表了在病理性条件下消除疼痛的内源性开关。
