比较双相子宫内膜消融术与水热消融术治疗月经过多的 5 年随访结果。

Five-year follow-up after comparing bipolar endometrial ablation with hydrothermablation for menorrhagia.

机构信息

From the Departments of Obstetrics and Gynecology, Máxima Medical Centre, Veldhoven, and AMC Amsterdam, Amsterdam, the Netherlands.

出版信息

Obstet Gynecol. 2011 Dec;118(6):1287-1292. doi: 10.1097/AOG.0b013e318236f7ed.

DOI:10.1097/AOG.0b013e318236f7ed

PMID:22105257

Abstract

OBJECTIVE

To evaluate the results of a previous study comparing bipolar radiofrequency endometrial ablation with hydrothermablation for the treatment of menorrhagia at 5-year follow-up.

METHOD

A double-blind, randomized, controlled trial was performed in a large teaching hospital in the Netherlands between March 2005 and August 2007. One-hundred sixty women with menorrhagia were randomly allocated to bipolar ablation or hydrothermablation. The results of follow-up at 12 months were previously reported. At 4-5 years of follow-up, a questionnaire was sent to all the participants to register amenorrhea rates, reinterventions, and patient satisfaction.

RESULTS

At 5-year follow-up, response rates were 90% and 83% in the bipolar group and hydrotherm group, respectively. Amenorrhea rates were 55.4% and 35.3% in the bipolar group and the hydrotherm group, respectively (relative risk [RR] 1.5, 95% confidence interval [CI] 1.05-2.3). The number of surgical reinterventions was 11 compared with 23 (RR 0.43, 95% CI 0.23-0.80). Overall, more women were satisfied in the bipolar group compared with the hydrotherm group.

CONCLUSION

After treatment, bipolar radiofrequency endometrial ablation system is more effective at 5 years than hydrothermablation in the treatment of menorrhagia.

LEVEL OF EVIDENCE

II.

摘要

目的

评估一项先前比较双极射频子宫内膜消融术与水热消融术治疗月经过多的研究在 5 年随访时的结果。

方法

2005 年 3 月至 2007 年 8 月，在荷兰的一家大型教学医院进行了一项双盲、随机、对照试验。将 160 名月经过多的妇女随机分配到双极消融或水热消融组。12 个月的随访结果先前已报道过。在 4-5 年的随访中，向所有参与者发送了一份问卷，以登记闭经率、再次干预和患者满意度。

结果

在 5 年随访时，双极组和水热组的应答率分别为 90%和 83%。双极组和水热组的闭经率分别为 55.4%和 35.3%（相对风险 [RR] 1.5，95%置信区间 [CI] 1.05-2.3）。与水热组相比，双极组的手术再次干预次数为 11 次，而水热组为 23 次（RR 0.43，95%CI 0.23-0.80）。总体而言，与水热组相比，更多的女性对双极组满意。