评估杏仁油在南美栗鼠动物模型中的耳毒性。
Assessment of the ototoxicity of almond oil in a chinchilla animal model.
机构信息
Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.
出版信息
Laryngoscope. 2011 Dec;121(12):2661-4. doi: 10.1002/lary.22385.
OBJECTIVES/HYPOTHESIS: Almond oil is frequently prescribed as a ceruminolytic, to soften ear wax or relieve ventilation tube occlusion. Ceruminolytics could lead to ototoxicity in the presence of a tympanic perforation. Reports on the safety of almond oil as a ceruminolytic is limited. The present study aimed to assess the effect of ototopic almond oil on hearing.
STUDY DESIGN
Prospective, randomized, controlled trial in a chinchilla animal model.
METHODS
Bilateral myringotomies were performed in 19 female chinchilla. One randomly selected ear received almond oil, whereas the other ear received saline applied transtympanically. Auditory Brainstem Response (ABR) testing was performed prior to application and at 14 and 30 days following application. Postmortem Scanning Electron Microscopy (SEM) images were obtained to assess cochlear hair cell status.
RESULTS
At 30 days following application, there was no significant change in ABR thresholds at 16, 20, or 25 kHz. No cochlear hair cell loss was observed with SEM.
CONCLUSIONS
In the chinchilla, when a tympanic perforation is present, almond oil does not seem to cause ototoxicity. Further studies are needed to better assess the effect of almond oil on hearing in humans.
目的/假设：杏仁油常被开为耳垢软化剂或通气管阻塞的治疗药物。然而，耳垢软化剂在鼓膜穿孔的情况下可能导致耳毒性。目前关于杏仁油作为耳垢软化剂的安全性的报告有限。本研究旨在评估耳内应用杏仁油对听力的影响。
研究设计
在南美栗鼠动物模型中进行的前瞻性、随机、对照试验。
方法
19 只雌性南美栗鼠均行双侧鼓膜切开术。一只耳朵随机接受杏仁油滴耳，另一只耳朵接受鼓室内滴注生理盐水。在应用前和应用后 14 天和 30 天进行听觉脑干反应（ABR）测试。进行死后扫描电子显微镜（SEM）图像检查以评估耳蜗毛细胞状态。
结果
在应用后 30 天，16、20 和 25 kHz 时的 ABR 阈值无显著变化。SEM 未观察到耳蜗毛细胞缺失。
结论
在鼓膜穿孔的情况下，杏仁油似乎不会引起耳毒性。需要进一步的研究来更好地评估杏仁油对人类听力的影响。
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