JC70：一种可检测常规处理组织切片上血管内皮相关抗原的新型单克隆抗体。

Parums D V, Cordell J L, Micklem K, Heryet A R, Gatter K C, Mason D Y

University of Oxford, Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Headington.

J Clin Pathol. 1990 Sep;43(9):752-7. doi: 10.1136/jcp.43.9.752.

A new monoclonal antibody, JC70, raised against a membrane preparation from a spleen affected by hairy cell leukaemia, recognises a membrane bound glycoprotein identical with that of the CD31 group of monoclonal antibodies. The antibody stains a fixation resistant epitope on endothelial cells in benign and malignant conditions in a wide variety of paraffin wax embedded tissue. JC70 stained malignant endothelial cells in 10 angiosarcomas with more consistency than monoclonal or polyclonal antibodies to factor VIII related antigen (FVIII-Rag). In four cases of Kaposi's sarcoma the antibody stained malignant endothelial cells but not spindle cells. It is concluded that antibody JC70 is of value for studying benign and malignant human vascular disorders in routinely processed tissue.

一种新的单克隆抗体JC70，是针对来自毛细胞白血病脾脏的膜制剂产生的，它识别一种与CD31单克隆抗体组所识别的膜结合糖蛋白相同的物质。该抗体在多种石蜡包埋组织的良性和恶性情况下，均能对内皮细胞上的一个抗固定表位进行染色。与针对因子VIII相关抗原（FVIII-Rag）的单克隆或多克隆抗体相比，JC70在10例血管肉瘤中对恶性内皮细胞的染色更具一致性。在4例卡波西肉瘤中，该抗体能对恶性内皮细胞染色，但不能对梭形细胞染色。结论是，抗体JC70对于研究常规处理组织中的人类良性和恶性血管疾病具有价值。