Silva Ruwan A, Albini Thomas A, Flynn Harry W
Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, 900 NW 17th Street, Miami, FL, 33136, USA.
J Ophthalmic Inflamm Infect. 2012 Jun;2(2):109-11. doi: 10.1007/s12348-011-0051-9. Epub 2011 Nov 26.
The aim of this study is to report a patient with multipe evanescent white dot syndrome (MEWDS) presenting with classic foveal granularity and pathology localized to the outer retina.
Case study methodology was used in the current study.
A 34-year-old Caucasian female presented with photopsias and blurry vision in her left eye. Examination, particularly the foveal granularity noted in her affected eye, was archetypal for the diagnosis of MEWDS. Fundus autofluorescence, fluorescein and indocyanine green angiography were also consistent with this diagnosis. Spectral-domain optical coherence tomography (SD-OCT) demonstrated increased retinal pigment epithelium granularity and disruption of the photoreceptor inner segment-outer segment junction subfoveally.
Foveal granularity may be the most specific feature of MEWDS with SD-OCT capable of localizing pathology to the outer retina-a historically controversial finding.
本研究旨在报告一例患有多发性一过性白点综合征（MEWDS）的患者，其表现为典型的黄斑区颗粒状改变，且病理学检查显示病变局限于视网膜外层。
本研究采用病例研究方法。
一名34岁的白种女性左眼出现闪光感和视力模糊。检查发现，尤其是患眼中的黄斑区颗粒状改变，是诊断MEWDS的典型表现。眼底自发荧光、荧光素和吲哚菁绿血管造影也与该诊断相符。频域光学相干断层扫描（SD-OCT）显示视网膜色素上皮颗粒增加，黄斑下光感受器内节-外节连接破坏。
黄斑区颗粒状改变可能是MEWDS最具特异性的特征，SD-OCT能够将病变定位到视网膜外层——这是一个历史上存在争议的发现。
