Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China.
Int J Obes (Lond). 2012 Sep;36(9):1203-8. doi: 10.1038/ijo.2011.222. Epub 2011 Nov 29.
Recent observational studies have reported that body fat distribution might be differentially associated with subclinical atherosclerosis. We previously reported that visceral fat area (VFA) ≥ 80 cm2 is the optimal cutoff for identifying abdominal obesity in Chinese subjects. We examined whether VFA ≥ 80 cm2 reflects the association between abdominal obesity and subclinical atherosclerosis, and if determination of the visceral fat quantity is useful for assessing subclinical atherosclerosis in asymptomatic individuals.
Participants (N=1005, men 515, women 490, 34-66 years) free of cardiovascular disease underwent magnetic resonance imaging and carotid ultrasound assessment to quantify VFA and carotid intima-media thickness (C-IMT). Overweight/obese subjects (body mass index (BMI) ≥ 25.0 kg m(-2)) had a higher C-IMT than lean subjects (BMI <25.0 kg m(-2)) (P<0.01). Subjects with VFA ≥ 80 cm2 had significantly higher C-IMT than those without abdominal obesity regardless of BMI (P<0.01). By multivariate regression analysis adjusted for anthropometric measurements and cardiovascular risk factors, waist circumference but not BMI was independently correlated with C-IMT in men (P<0.001). Similar findings were observed with an accurate obesity indices adjusted model, which showed that VFA was an independent risk factor for increased C-IMT in men but not in women.
VFA 80 cm2 effectively identified carotid atherosclerosis for both lean and obese individuals in middle-aged Chinese men.
最近的观察性研究报告称，体脂分布可能与亚临床动脉粥样硬化存在差异相关性。我们之前的研究报告称，内脏脂肪面积（VFA）≥80cm²是识别中国人群腹部肥胖的最佳截断值。我们研究了 VFA≥80cm²是否反映了腹部肥胖与亚临床动脉粥样硬化之间的关联，以及确定内脏脂肪量是否有助于评估无症状个体的亚临床动脉粥样硬化。
共有 1005 名参与者（男性 515 名，女性 490 名，年龄 34-66 岁），无心血管疾病，接受磁共振成像和颈动脉超声评估以定量测量 VFA 和颈动脉内膜中层厚度（C-IMT）。超重/肥胖者（BMI≥25.0kg/m²）的 C-IMT 高于瘦者（BMI<25.0kg/m²）（P<0.01）。无论 BMI 如何，VFA≥80cm²的受试者的 C-IMT 明显高于无腹部肥胖的受试者（P<0.01）。通过调整人体测量学和心血管危险因素的多变量回归分析，腰围而不是 BMI 与男性的 C-IMT 独立相关（P<0.001）。在一个准确的肥胖指数调整模型中也观察到了类似的发现，该模型显示 VFA 是男性而非女性 C-IMT 增加的独立危险因素。
VFA≥80cm² 可有效识别中年中国男性中瘦和肥胖个体的颈动脉粥样硬化。
