Leroy C, Collignon-Brach J
Centre Hospitalier Universitaire, Clinique ophtalmologique, Liège, Belgique.
J Fr Ophtalmol. 1990;13(1-2):29-32.
In a limited group of open angle glaucoma patients treated twice daily with timoptol 0.5% and having by this treatment a mean intra-ocular pressure of 21-22 mmHg, the association of timoptol 0.5% with pilocarpine 2% respectively, lowered the intra-ocular pressure to an average of 17.8 mmHg and 16.6 mmHg after one and three weeks of continuous treatment. For this study, the patients have been divided into 3 groups: A group treated with timoptol 0.5% alone throughout the 49 days of the study. A group treated with timoptol 0.5%-pilocarpine 2% (timpilo 2) from day 21 to day 49. A final group treated with timoptol 0.5% until day 21 and then with timoptol 0.5%-pilocarpine 4% (timpilo 4) through out day 49. These patients stopped the treatment before the end of the study. Intra-ocular pressures were measured on days 0, 21 and 49. We found a higher drop of pressure (-4.8 mmHg) in the timpilo 2 group than in the timoptol 0.5% group (-1 mmHg) before instillation as well as 2 hours afterwards (-5.25 mmHg and -2 mmHg respectively). The secondary local effects were due to miotics agents. The secondary systemic effects were those inherent to beta-blockers. These results are comparable with a multicentric study of 220 patients, therefore statistically significant.
在一组有限的开角型青光眼患者中，他们每天使用0.5%噻吗洛尔治疗两次，通过这种治疗平均眼压为21 - 22 mmHg，分别将0.5%噻吗洛尔与2%毛果芸香碱联合使用，在持续治疗1周和3周后，眼压分别降至平均17.8 mmHg和16.6 mmHg。在本研究中，患者被分为3组：一组在整个49天的研究中仅用0.5%噻吗洛尔治疗。一组从第21天至第49天用0.5%噻吗洛尔 - 2%毛果芸香碱（噻吗毛果2）治疗。最后一组在第21天前用0.5%噻吗洛尔治疗，然后在第49天全程用0.5%噻吗洛尔 - 4%毛果芸香碱（噻吗毛果4）治疗。这些患者在研究结束前停止治疗。在第0天、第21天和第49天测量眼压。我们发现，在滴注前以及滴注后2小时，噻吗毛果2组的眼压下降幅度（-4.8 mmHg）高于0.5%噻吗洛尔组（-1 mmHg）（分别为-5.25 mmHg和-2 mmHg）。次要的局部效应是由缩瞳剂引起的。次要的全身效应是β受体阻滞剂所固有的。这些结果与一项对220名患者的多中心研究结果相当，因此具有统计学意义。
