Castro-Bouzas Daniel, Prieto-González Ángel, Serramito-García Ramón, Santín-Amo José M, Reyes-Santías Rosa M, Allut Alfredo G, Gelabert-González Miguel
Servicio de Neurocirugía, Departamento de Cirugía, Universidad de Santiago de Compostela, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, España.
Rev Neurol. 2011 Dec 16;53(12):735-8.
Primary bone lymphomas account for 3-7% of all malignant bone tumours and less than 2% of lymphomas in adults. Having the cranial vault as their primary location is very infrequent.
A 59-year-old female who presented a painful tumour on the cranial vault which, following radical surgical removal, was found to be an ALK-negative primary large-cell lymphoma.
After reviewing the literature we believe that this is the first case of cranial vault lymphoma in which the translocation of the ALK protein-producing gene has been studied.
原发性骨淋巴瘤占所有恶性骨肿瘤的3% - 7%,在成人淋巴瘤中占比不到2%。以颅顶为主要发病部位的情况非常罕见。
一名59岁女性,颅顶出现疼痛性肿瘤,根治性手术切除后发现是ALK阴性原发性大细胞淋巴瘤。
查阅文献后,我们认为这是首例对产生ALK蛋白的基因易位进行研究的颅顶淋巴瘤病例。