Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15261, USA.
Arch Pathol Lab Med. 2011 Dec;135(12):1601-5. doi: 10.5858/arpa.2009-0713-RS.
Primary adenocarcinoma of urinary bladder is an uncommon neoplasm and is a source of diagnostic confusion with adenocarcinomas arising in adjacent organs, especially colon. These tumors show varied histologic picture and degree of differentiation. Clinical association with bladder exstrophy and schistosomiasis has been well documented. Primary bladder adenocarcinomas have overlapping histologic and immunohistochemical features with adenocarcinomas arising from other primary sites and the suggested immunohistochemical panel includes cytokeratins 7 and 20, 34βE12, thrombomodulin, CDX2, and β-catenin. Clinical, imaging, histologic, and immunohistochemical correlation should be done while rendering this diagnosis, as prognosis and therapeutic options for primary versus metastatic adenocarcinoma vary widely.
原发性膀胱腺癌是一种罕见的肿瘤，与邻近器官（尤其是结肠）的腺癌相比，其在诊断上容易混淆。这些肿瘤具有不同的组织学表现和分化程度。文献已经充分记载了其与膀胱外翻和血吸虫病的临床关联。原发性膀胱腺癌与来自其他原发部位的腺癌具有重叠的组织学和免疫组织化学特征，建议的免疫组织化学标志物包括细胞角蛋白 7 和 20、34βE12、血栓调节蛋白、CDX2 和β-连环蛋白。在做出这一诊断时，应进行临床、影像学、组织学和免疫组织化学相关性分析，因为原发性与转移性腺癌的预后和治疗选择差异很大。
