Lattová V, Procházka M, Ulehlová J
Porodnicko-gynekologická klinika FN, Olomouc.
Ceska Gynekol. 2011 Oct;76(5):367-70.
Generation of thrombin is pivotal step of hemostasis, according to in vitro experiments, thrombin generation occurs in 2 phases. Initially small amount of thrombin is produced after activation of factor X by complex TF/FVIIa. Thrombin multiplies coagulation by activation of platelets, F V a F VIII. Complex of TF/FVIIa activates also F VIII a, F IX, F VIII and FIXa and its binding to surface of platelets, which activates F X and products quantity of thrombin and leads formation of fibrin and finaly to triggering clotting.
Review.
Department of Obstetrics and Gynecology, University Hospital Olomouc.
凝血酶的生成是止血的关键步骤，根据体外实验，凝血酶的生成分为两个阶段。最初，在组织因子/活化因子VII（TF/FVIIa）复合物激活因子X后会产生少量凝血酶。凝血酶通过激活血小板、活化因子V（FVa）和活化因子VIII（FVIII）来增强凝血过程。TF/FVIIa复合物还会激活FVIIIa、因子IX（FIX）、FVIII和FIXa，并使其与血小板表面结合，从而激活因子X并产生大量凝血酶，导致纤维蛋白形成，最终引发凝血。
综述。
奥洛穆茨大学医院妇产科。
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