临床免疫学综述系列；关注过敏：嗜碱性粒细胞作为评估免疫调节的生物标志物。
Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation.
机构信息
Massachusetts General Hospital, Center for Immunology and Inflammatory Diseases, Boston, MA, USA.
出版信息
Clin Exp Immunol. 2012 Jan;167(1):59-66. doi: 10.1111/j.1365-2249.2011.04503.x.
Abstract
Allergen-specific immunotherapy is an effective clinical treatment for hypersensitivity to many allergens. Studies of basophils during immunotherapy have provided insight into underlying immune mechanisms and support the potential use of basophil activation as a biomarker of clinical outcomes. This review examines the evidence for different pathways of basophil modulation associated with various forms of immunotherapy. Better understanding the molecular mechanisms of basophil activation and desensitization and the relationship between suppression of these effector cells to clinical outcomes holds promise for further development and improvement in potential therapies for allergic diseases.
摘要
变应原特异性免疫治疗是治疗多种变应原过敏的有效临床治疗方法。免疫治疗期间对嗜碱性粒细胞的研究提供了对潜在免疫机制的深入了解，并支持将嗜碱性粒细胞活化作为临床结果的生物标志物的潜在用途。本综述检查了与各种形式的免疫治疗相关的嗜碱性粒细胞调节的不同途径的证据。更好地了解嗜碱性粒细胞激活和脱敏的分子机制以及这些效应细胞对临床结果的抑制之间的关系，有望为过敏性疾病的潜在治疗方法的进一步发展和改进提供帮助。
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