含不对称嵌入配体的钌（II）配合物的 DNA 结合和光裂解研究。
DNA-binding and photocleavage studies of ruthenium(II) complexes containing asymmetric intercalative ligand.
机构信息
College of Chemistry and Chemical Engineering, Hunan University of Arts and Science, ChangDe 415000, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Feb;86:554-61. doi: 10.1016/j.saa.2011.11.014. Epub 2011 Nov 18.
A novel asymmetric ligand 2-(pyridine-2-yl)-1-H-imidazo[4,5-i]dibenzo[2,3-a:2',3'-c]phenazine (pidbp) and its ruthenium complexes Ru(L)(2)(pidbp) (L=bpy (2, 2'- bipyridine), phen (1, 10 - phenanthroline)), have been synthesized and characterized by elemental analysis, ES-MS, (1)H NMR. Various methods support the conclusion that both Ru(II) complexes can intercalate into DNA base pairs. Complex Ru(bpy)(2)(pidbp)4 exhibits its DNA "molecular light switch" properties. Furthermore, the two complexes are efficient DNA-photocleavers under irradiation at 365 nm, and complex 5 exhibits a stronger DNA-photocleavage efficiency than complex 4. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen.
一种新型不对称配体 2-(吡啶-2-基)-1-H-咪唑并[4,5-i]二苯并[2,3-a:2',3'-c]吩嗪（pidbp）及其钌配合物[Ru(L)(2)(pidbp)] 2+（L=bpy（2,2'-联吡啶），phen（1,10-菲咯啉））已通过元素分析、ES-MS、（1）H NMR 进行了合成和表征。各种方法都支持这两个 Ru(II) 配合物可以嵌入 DNA 碱基对的结论。配合物[Ru(bpy)(2)(pidbp)] 2+4 表现出其 DNA“分子光开关”特性。此外，这两个配合物在 365nm 照射下是有效的 DNA 光裂物，配合物 5 表现出比配合物 4 更强的 DNA 光裂物效率。DNA 断裂的机制是通过生成单线态氧的氧化过程。
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