Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi-do, Republic of Korea.
Clin Chim Acta. 2012 Feb 18;413(3-4):511-5. doi: 10.1016/j.cca.2011.11.019. Epub 2011 Nov 25.
Although serum carcinoembryonic antigen (CEA) levels reflect tumor volume in rectal cancer patients intrapersonally, it is unclear interpersonally. We determined the correlation between pretreatment serum CEA levels and tumor volume.
A total of 489 patients with locally advanced primary rectal cancer who underwent preoperative chemoradiotherapy followed by surgery between October 2001 and April 2007 were retrospectively evaluated. CEA levels were measured by chemiluminescent microparticle immunoassay, and magnetic resonance (MR) volumetry was performed using MR data. The correlation between CEA levels and tumor volume was assessed using linear regression analysis and one-way analysis of variance. The prognostic values of CEA levels and tumor volume for survival were evaluated.
There was no significant correlation between CEA levels and tumor volume. The five-year overall survival and disease-free survival were 89.0%, 80.6% and 82.9%, and 72.0%, 70.0% and 60.3% in patients with CEA levels of ≤3 ng/ml, >3-10 ng/ml, and >10 ng/ml, respectively. Tumor volume had no prognostic value for either overall survival or disease-free survival
Pretreatment serum CEA levels were not correlated with tumor volume. While there was no correlation between tumor volume and survival, there was a positive correlation between CEA levels and survival.
虽然血清癌胚抗原（CEA）水平在个体内反映直肠癌患者的肿瘤体积，但在个体间尚不清楚。我们确定了术前血清 CEA 水平与肿瘤体积之间的相关性。
回顾性评估了 2001 年 10 月至 2007 年 4 月期间接受术前放化疗后手术治疗的 489 例局部晚期原发性直肠癌患者。CEA 水平通过化学发光微粒子免疫测定法测量，MR 体绘制通过 MR 数据进行。使用线性回归分析和单因素方差分析评估 CEA 水平与肿瘤体积之间的相关性。评估了 CEA 水平和肿瘤体积对生存的预后价值。
CEA 水平与肿瘤体积之间无显著相关性。CEA 水平≤3ng/ml、>3-10ng/ml 和>10ng/ml 的患者的 5 年总生存率和无病生存率分别为 89.0%、80.6%和 72.0%、70.0%和 60.3%。肿瘤体积对总生存率和无病生存率均无预后价值。
术前血清 CEA 水平与肿瘤体积无关。虽然肿瘤体积与生存之间没有相关性，但 CEA 水平与生存之间存在正相关。
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