Department of Anesthesiology, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA.
Pain Med. 2012 Jan;13(1):96-106. doi: 10.1111/j.1526-4637.2011.01285.x. Epub 2011 Dec 5.
Interventional pain management techniques play an important role in the multidisciplinary approach to management of complex regional pain syndrome (CRPS). In this preliminary study we compared the efficacy of continuous stellate ganglion (CSG) block with that of continuous infraclavicular brachial plexus (CIBP) block in management of CRPS type I of upper extremity.
Thirty-three patients with CRPS type I of upper extremity were randomly assigned to either CSG or CIBP group. Patients were treated for 1 week with continuous infusion of 0.125% bupivacaine at 2and 5mL/h, respectively. Catheter was removed at 1 week and patients were followed up for 4 weeks. The outcome was evaluated in terms of neuropathic pain scale score (NPSS), edema scores (Grades 0-2), and range of motion (ROM) of all upper extremity joints (Grades 0-2).
CIBP group showed statistically significant improvement in NPSS compared with CSG group during the first 12 hours after the procedures (P value <0.05). After 12 hours, the NPSS was comparable between the groups. At 4 weeks, both groups showed clinically significant improvement in edema score and ROM of all upper extremity joints when compared with the baseline.
This preliminary study suggests that CIBP block and CSG block may be feasible and effective interventional techniques for the management of CRPS type I of upper extremities. Hence, we recommend a larger well-randomized, well-controlled, clinical trial to confirm our findings and determine if any significant difference exists between the groups in terms of long-term pain relief and functional restoration.
探讨连续星状神经节阻滞(CSG)与连续锁骨下臂丛阻滞(CIBP)治疗上肢复杂性区域疼痛综合征(CRPS)Ⅰ型的疗效。
33 例上肢 CRPS Ⅰ型患者随机分为 CSG 组或 CIBP 组。两组患者分别采用 0.125%布比卡因持续输注,速率分别为 2 和 5mL/h,治疗 1 周。1 周时拔除导管,随访 4 周。采用神经病理性疼痛量表评分(NPSS)、肿胀评分(0-2 级)和所有上肢关节活动度(ROM)评分(0-2 级)评估疗效。
CIBP 组患者在治疗后 12 小时内 NPSS 评分显著优于 CSG 组(P<0.05),12 小时后两组间 NPSS 评分无显著差异。4 周时,两组患者肿胀评分和所有上肢关节 ROM 评分均较基线显著改善。
CIBP 阻滞和 CSG 阻滞可能是治疗上肢 CRPS Ⅰ型的可行且有效的介入技术。因此,我们建议进行更大规模的、随机对照临床试验,以验证我们的发现,并确定两组在长期疼痛缓解和功能恢复方面是否存在任何显著差异。