对迷走神经传入刺激诱导的反射性气管收缩的抑制性调节。

Inhibitory modulation of the reflex tracheal constriction induced by afferent vagal stimulation.

作者信息

Misawa M, Takahashi Y, Kamei J, Hosokawa T, Yanaura S

机构信息

Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

出版信息

Jpn J Pharmacol. 1990 Aug;53(4):506-9. doi: 10.1254/jjp.53.506.

DOI:10.1254/jjp.53.506

PMID:2214373

Abstract

Afferent cervical vagal electrical stimulation caused a reflex tracheal constriction. Atropine changed the tracheal constriction into a tracheal dilatation that was almost inhibited by propranolol. In the hypertonic trachea with 5-hydroxytryptamine, a reflex dilatation following a constriction was observed by afferent vagal stimulation. The reflex dilatation was inhibited about 50% by propranolol and was abolished by hexamethonium. These results suggest that the adrenergic and nonadrenergic inhibitory innervations may mediate the reflex tracheal dilatation, especially in a hypertonic tracheal condition.

摘要

颈迷走神经传入电刺激引起反射性气管收缩。阿托品使气管收缩转变为气管扩张，而普萘洛尔几乎可抑制这种扩张。在含有5-羟色胺的高渗气管中，迷走神经传入刺激可引起收缩后出现反射性扩张。这种反射性扩张被普萘洛尔抑制约50%，并被六甲铵消除。这些结果表明，肾上腺素能和非肾上腺素能抑制性神经支配可能介导反射性气管扩张，尤其是在高渗气管状态下。