Leiba S, Kaufman H, Winkelsberg G, Bahary C
Isr J Med Sci. 1979 May;15(5):434-7.
A considerable number of women receiving antiovulatory compounds or estrogens complain of weakness and fatigability, suggesting a state of clinical hypoadrenalism. For this reason, levels of plasma ACTH and plasma cortisol were determined in 25 women with such complaints both during treatment and at various intervals after cessation of this treatment. The results obtained showed that there was a significant inhibition of ACTH secretion during long-term treatment with antiovulatory compounds or estrogens, and in half of the cases, there was a delay in normalization of the pituitary-adrenal axis following interruption of the drug, supporting a state of transitory hypoadrenalism.
相当多接受抗排卵化合物或雌激素治疗的女性抱怨虚弱和疲劳，提示存在临床肾上腺功能减退状态。因此，对25名有此类症状的女性在治疗期间及停药后的不同时间段测定了血浆促肾上腺皮质激素（ACTH）水平和血浆皮质醇水平。所得结果表明，在长期使用抗排卵化合物或雌激素治疗期间，ACTH分泌受到显著抑制，并且在半数病例中，停药后垂体 - 肾上腺轴恢复正常存在延迟，这支持了暂时性肾上腺功能减退状态。
