神经源性星形胶质细胞及其糖缀合物：不再仅仅是“胶水”了。
Neurogenic astrocytes and their glycoconjugates: not just "glue" anymore.
作者信息
Steindler Dennis A
机构信息
Department of Neuroscience, The Evelyn F. and William L. McKnight Brain Institute, The University of Florida, Gainesville, FL, USA.
出版信息
Methods Mol Biol. 2012;814:9-22. doi: 10.1007/978-1-61779-452-0_2.
Cells with certain attributes of very immature astroglial cells and their radial precursors can act as stem and/or progenitor cells during developmental and persistent neurogenesis. Neural stem/progenitor cells both express and are affected by a variety of developmentally regulated macromolecules and growth factors, and such signaling or recognition molecules are being uncovered through extensive genomic and proteomic studies, as well as tested using in vitro/in vivo cell growth bioassays. Glycosylated molecules are appreciated as distinct signaling molecules during morphogenesis in a variety of tissues and organs, with glycoconjugates (glycoproteins, glycolipids, and glycosaminoglycans) serving as mediators for the interactions of cells with each other and their substrates, to confer growth and differentiation cues to precursor cells in search of identity. Neurogenic astrocytes and associated glycoconjugates, especially extracellular matrix molecules, are discussed in the context of neurogenesis and stem/progenitor cell growth, fate choice, and differentiation.
具有某些非常不成熟的星形胶质细胞及其放射状前体细胞属性的细胞，在发育性和持续性神经发生过程中可充当干细胞和/或祖细胞。神经干细胞/祖细胞既表达多种受发育调控的大分子和生长因子，又受其影响，并且通过广泛的基因组和蛋白质组学研究正在发现此类信号或识别分子，同时也在使用体外/体内细胞生长生物测定法进行测试。糖基化分子在多种组织和器官的形态发生过程中被视为独特的信号分子，糖缀合物（糖蛋白、糖脂和糖胺聚糖）作为细胞彼此之间及其与底物相互作用的介质，为寻求身份的前体细胞赋予生长和分化线索。本文在神经发生以及干细胞/祖细胞生长、命运选择和分化的背景下讨论了神经源性星形胶质细胞和相关糖缀合物，尤其是细胞外基质分子。
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