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躯干皮肤平滑肌肉瘤

Cutaneous leiomyosarcoma on the trunk.

作者信息

André Marisa Carpinteiro, Antunes Joana Veiga, Reis Miguel Duarte, Filipe Paulo Leal, Almeida Luís Miguel Soares de

机构信息

Clínica Universitária de Dermatologia, Hospital de Santa Maria, Lisboa, Portugal.

出版信息

An Bras Dermatol. 2011 Sep-Oct;86(5):999-1002. doi: 10.1590/s0365-05962011000500021.

Abstract

Cutaneous leiomyosarcoma is a relatively uncommon tumor that accounts for 7% of all soft tissue sarcomas. It occurs more frequently in males between 50-70 years and only 10-15% of cases are located on the trunk. Radiotherapy and previous trauma have been implied as risk factors. We report the case of a 57 year-old male with an eight-month history of a hard painless erythematous-violaceous tumor on the presternal region. Histopathology evidenced a malignant spindle cell tumor, "cigar" shaped, with pleomorphic nuclei and a high mitotic index that occupied the entire dermal thickness. Immunohistochemical staining of the tumor cells was positive for smooth muscle actin, desmin and vimentin and negative for S-100 protein and pan-cytokeratin, which supported the diagnosis of dermal leiomyosarcoma. Radical surgery was performed to remove the tumor.

摘要

皮肤平滑肌肉瘤是一种相对罕见的肿瘤,占所有软组织肉瘤的7%。它在50至70岁的男性中更为常见,仅有10%至15%的病例位于躯干。放疗和既往创伤被认为是危险因素。我们报告一例57岁男性,其胸骨前区有一个坚硬、无痛、红斑紫罗兰色肿瘤,病史8个月。组织病理学显示为恶性梭形细胞瘤,呈“雪茄”状,核多形性,有丝分裂指数高,占据整个真皮厚度。肿瘤细胞免疫组化染色平滑肌肌动蛋白、结蛋白和波形蛋白呈阳性,S-100蛋白和泛细胞角蛋白呈阴性,支持真皮平滑肌肉瘤的诊断。行根治性手术切除肿瘤。

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