Department of Radiology, Tokyo Dental and Medical University, Tokyo, Japan.
Clin Nucl Med. 2012 Jan;37(1):39-43. doi: 10.1097/RLU.0b013e3182393390.
The aim of this study was to assess the utility of positron emission tomography/computed tomography (PET/CT) for the investigation of patients with suspected paraneoplastic neurologic syndrome (PNS).
We reviewed the whole-body fluorodeoxyglucose (FDG) PET/CT studies (ordered by the neurology department) performed at our hospital between December 2005 and November 2010; 27 cases (16 men, 11 women; mean age, 65 years) who were suspected of having PNS were selected.
Of the 27 patients, 6 (22%) had an abnormal FDG uptake. Of these 6 patients, 5 (19%) were histologically confirmed as having a malignancy. Of the 27 patients, 7 were tested for the presence of well-characterized paraneoplastic antibodies (anti-Hu, anti-Ri, anti-Yo); 1 had anti-Hu, but the patient did not have an abnormal FDG uptake or malignancy.
PET/CT may be a useful screening tool for patients with clinically suspected PNS who do not exhibit well-characterized paraneoplastic antibodies. Therefore, we recommended that PET/CT should be performed for patients with clinically suspicious PNS regardless of the presence of well-characterized paraneoplastic antibodies.
本研究旨在评估正电子发射断层扫描/计算机断层扫描（PET/CT）在疑似副肿瘤神经综合征（PNS）患者中的应用价值。
我们回顾了 2005 年 12 月至 2010 年 11 月期间在我院进行的全身氟脱氧葡萄糖（FDG）PET/CT 检查（由神经科医生开单）；选择了 27 例疑似 PNS 的患者（男 16 例，女 11 例；平均年龄 65 岁）。
27 例患者中，有 6 例（22%）出现 FDG 摄取异常。这 6 例患者中，有 5 例（19%）经组织学证实患有恶性肿瘤。在这 27 例患者中，有 7 例检测到特征明确的副肿瘤抗体（抗 Hu、抗 Ri、抗 Yo）；其中 1 例为抗 Hu，但患者无异常 FDG 摄取或恶性肿瘤。
对于未表现出特征明确的副肿瘤抗体的临床疑似 PNS 患者，PET/CT 可能是一种有用的筛查工具。因此，我们建议对于临床疑似 PNS 的患者，无论是否存在特征明确的副肿瘤抗体，都应进行 PET/CT 检查。
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