双三唑类化合物对基于核糖的荧光传感器的影响。
Effect of bis-triazoles on a ribose-based fluorescent sensor.
机构信息
Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan.
出版信息
Luminescence. 2011 Nov-Dec;26(6):518-22. doi: 10.1002/bio.1263. Epub 2010 Dec 29.
We synthesized two ribosyl-based fluorescent sensors. Both sensors have an anthracene as the fluorophore, but they differ in the recognition site for metal ions. One (3) has two ribosyl esters, and the other (6) has two triazole groups linked to two ribosyl esters. Among the metal ions examined in MeOH, compound 3 displayed a large chelation-enhanced fluorescence (CHEF) effect with Hg(2+) and Cu(2+) ions, and compound 6 displayed a large chelation-quenched fluorescence (CHQF) effect with Cu(2+) and Ni(2+) ions. The results demonstrated that the absence (sensor 3) and presence (sensor 6) of an incorporated bis-triazole group in a ribosyl-based fluorescent sensor conferred different preferences and distinct binding modes for metal ions.
我们合成了两种基于核糖的荧光传感器。这两种传感器都以蒽为荧光团，但它们在识别金属离子的位点上有所不同。一种（3）有两个核糖酯，另一种（6）有两个三唑基团连接到两个核糖酯上。在甲醇中检测到的金属离子中，化合物 3 对 Hg(2+)和 Cu(2+)离子显示出大的螯合增强荧光（CHEF）效应，化合物 6 对 Cu(2+)和 Ni(2+)离子显示出大的螯合猝灭荧光（CHQF）效应。结果表明，在基于核糖的荧光传感器中是否存在（传感器 3）和存在（传感器 6）一个整合的双三唑基团赋予了金属离子不同的偏好和独特的结合模式。
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