• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

常年性变应性鼻炎鼻黏膜中局部表达FOXP3的T细胞与Th1-Th2平衡的相关性

Correlation of Local FOXP3-Expressing T Cells and Th1-Th2 Balance in Perennial Allergic Nasal Mucosa.

作者信息

Shirasaki Hideaki, Kanaizumi Etsuko, Seki Nobuhiko, Himi Tetsuo

机构信息

Department of Otolaryngology, School of Medicine, Sapporo Medical University, S-1 W-16, Chu-ku, Sapporo 060-8543, Japan.

出版信息

Int J Otolaryngol. 2011;2011:259867. doi: 10.1155/2011/259867. Epub 2011 Nov 17.

DOI:10.1155/2011/259867
PMID:22164170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3227500/
Abstract

Regulatory T cells (Treg) play some important roles in allergic rhinitis. The most specific marker for Treg is FOXP3, a recently identified transcription factor that is essential for Treg development. In order to clarify the levels of Treg in allergic nasal mucosa, we studied the relationship between FOXP3-expressing cells and Th1-Th2 balance in nasal mucosa by means of immunohistochemistry. Human turbinates were obtained after turbinectomy from 26 patients (14 patients with perennial allergic rhinitis and 12 patients with nonallergic rhinitis). To identify the cells expressing the FOXP3 protein, double immunostaining was performed by using anti-FOXP3 antibody and anti-CD3 antibody. There was no significant difference in the percentage of FOXP3+CD3+ cells among CD3+ cells in the nasal mucosa of two groups. The proportion of FOXP3+CD3+ cells tend to be correlated positively with GATA3+CD3+ cells/T-bet+CD3+ cells ratio (R = 0.56, P = 0.04). A positive correlation with GATA3+CD3+/T-bet+CD3+ ratio and FOXP3+CD3+/CD3+ ratio suggests the role of local regulatory T cells as a minimal control of the chronic allergen exposure in nasal mucosa.

摘要

调节性T细胞（Treg）在变应性鼻炎中发挥着一些重要作用。Treg最特异的标志物是FOXP3，它是一种最近发现的转录因子，对Treg的发育至关重要。为了阐明变应性鼻黏膜中Treg的水平，我们通过免疫组织化学研究了鼻黏膜中表达FOXP3的细胞与Th1-Th2平衡之间的关系。从26例患者（14例常年性变应性鼻炎患者和12例非变应性鼻炎患者）的鼻甲切除术中获取人鼻甲组织。为了鉴定表达FOXP3蛋白的细胞，使用抗FOXP3抗体和抗CD3抗体进行双重免疫染色。两组鼻黏膜中CD3 +细胞中FOXP3 + CD3 +细胞的百分比无显著差异。FOXP3 + CD3 +细胞的比例倾向于与GATA3 + CD3 +细胞/T-bet + CD3 +细胞的比例呈正相关（R = 0.56，P = 0.04）。GATA3 + CD3 + /T-bet + CD3 +比例与FOXP3 + CD3 + /CD3 +比例呈正相关，提示局部调节性T细胞在鼻黏膜慢性变应原暴露的最小控制中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/124a0826aa57/IJOL2011-259867.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/932fec20cd22/IJOL2011-259867.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/c03e4ce11c28/IJOL2011-259867.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/4d3706e36d52/IJOL2011-259867.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/6adbe301fe98/IJOL2011-259867.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/124a0826aa57/IJOL2011-259867.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/932fec20cd22/IJOL2011-259867.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/c03e4ce11c28/IJOL2011-259867.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/4d3706e36d52/IJOL2011-259867.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/6adbe301fe98/IJOL2011-259867.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bc/3227500/124a0826aa57/IJOL2011-259867.005.jpg

相似文献

1
Correlation of Local FOXP3-Expressing T Cells and Th1-Th2 Balance in Perennial Allergic Nasal Mucosa.常年性变应性鼻炎鼻黏膜中局部表达FOXP3的T细胞与Th1-Th2平衡的相关性
Int J Otolaryngol. 2011;2011:259867. doi: 10.1155/2011/259867. Epub 2011 Nov 17.
2
Derp1-modified dendritic cells attenuate allergic inflammation by regulating the development of T helper type1(Th1)/Th2 cells and regulatory T cells in a murine model of allergic rhinitis.在变应性鼻炎小鼠模型中，Derp1修饰的树突状细胞通过调节1型辅助性T细胞（Th1）/2型辅助性T细胞（Th2）和调节性T细胞的发育来减轻变应性炎症。
Mol Immunol. 2017 Oct;90:172-181. doi: 10.1016/j.molimm.2017.07.015. Epub 2017 Aug 9.
3
Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β in Guinea Pigs.富氢生理盐水通过逆转 Th1/Th2 失衡和上调 CD4+CD25+Foxp3+调节性 T 细胞、白细胞介素-10 和膜结合转化生长因子-β来改善豚鼠变应性鼻炎。
Inflammation. 2018 Feb;41(1):81-92. doi: 10.1007/s10753-017-0666-6.
4
Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa.草花粉免疫疗法可诱导鼻黏膜中表达Foxp3的CD4+ CD25+细胞产生。
J Allergy Clin Immunol. 2008 Jun;121(6):1467-72, 1472.e1. doi: 10.1016/j.jaci.2008.03.013. Epub 2008 Apr 18.
5
Reduced T-bet in addition to enhanced STAT6 and GATA3 expressing T cells contribute to human allergen-induced late responses.减少 T-bet 的表达，同时增强 STAT6 和 GATA3 表达的 T 细胞有助于人类变应原诱导的晚期反应。
Clin Exp Allergy. 2012 Jun;42(6):891-900. doi: 10.1111/j.1365-2222.2012.04003.x.
6
Effects of pollen and nasal glucocorticoid on FOXP3+, GATA-3+ and T-bet+ cells in allergic rhinitis.花粉和鼻用糖皮质激素对变应性鼻炎中FOXP3 +、GATA - 3 +和T - bet +细胞的影响。
Allergy. 2007 Sep;62(9):1007-13. doi: 10.1111/j.1398-9995.2007.01420.x.
7
Effects of allergen-specific immunotherapy on functions of helper and regulatory T cells in patients with seasonal allergic rhinitis.变应原特异性免疫治疗对季节性变应性鼻炎患者辅助性和调节性 T 细胞功能的影响。
Eur Cytokine Netw. 2011 Mar;22(1):15-23. doi: 10.1684/ecn.2011.0277.
8
Regulatory-T, T-helper 1, and T-helper 2 cell differentiation in nasal mucosa of allergic rhinitis with olive pollen sensitivity.变应性鼻炎伴橄榄花粉过敏患者鼻黏膜中调节性 T、辅助性 T 细胞 1 和辅助性 T 细胞 2 的分化。
Int Arch Allergy Immunol. 2012;157(4):349-53. doi: 10.1159/000329159. Epub 2011 Nov 24.
9
Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation.Notch信号通路通过抑制Foxp3表达和调节性T细胞分化促进变应性鼻炎的发展。
Int Arch Allergy Immunol. 2019;178(1):33-44. doi: 10.1159/000493328. Epub 2018 Nov 2.
10
Experimentally induced accumulation of Foxp3⁺ T cells in upper airway allergy.实验诱导 Foxp3⁺ T 细胞在上呼吸道变应性中的积累。
Clin Exp Allergy. 2011 Jul;41(7):954-62. doi: 10.1111/j.1365-2222.2011.03710.x. Epub 2011 Mar 21.

引用本文的文献

1
Interaction between nasal epithelial cells and Tregs in allergic rhinitis responses to allergen via CCL1/CCR8.变应性鼻炎中鼻上皮细胞与调节性T细胞通过CCL1/CCR8对变应原产生反应的相互作用。
Front Immunol. 2025 Feb 20;16:1526081. doi: 10.3389/fimmu.2025.1526081. eCollection 2025.
2
Effect of adipose mesenchymal stem cell-derived exosomes on allergic rhinitis in mice.脂肪间充质干细胞来源的外泌体对小鼠变应性鼻炎的影响
Heliyon. 2024 Dec 19;11(1):e41340. doi: 10.1016/j.heliyon.2024.e41340. eCollection 2025 Jan 15.
3
Exploration of Allergic Rhinitis: Epidemiology, Predisposing Factors, Clinical Manifestations, Laboratory Characteristics, and Emerging Pathogenic Mechanisms.

本文引用的文献

1
Experimentally induced accumulation of Foxp3⁺ T cells in upper airway allergy.实验诱导 Foxp3⁺ T 细胞在上呼吸道变应性中的积累。
Clin Exp Allergy. 2011 Jul;41(7):954-62. doi: 10.1111/j.1365-2222.2011.03710.x. Epub 2011 Mar 21.
2
Decreased FoxP3 gene expression in the nasal secretions from patients with allergic rhinitis.
Otolaryngol Head Neck Surg. 2009 Feb;140(2):197-201. doi: 10.1016/j.otohns.2008.08.016.
3
Effect of sublingual immunotherapy with grass monomeric allergoid on allergen-specific T-cell proliferation and interleukin 10 production.草单体制剂舌下免疫疗法对变应原特异性T细胞增殖及白细胞介素10产生的影响。
变应性鼻炎的探索：流行病学、诱发因素、临床表现、实验室特征及新出现的致病机制
Cureus. 2024 Oct 14;16(10):e71409. doi: 10.7759/cureus.71409. eCollection 2024 Oct.
4
HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway.人骨髓间充质干细胞来源的外泌体通过调控 miR-146a-5p/SERPINB2 通路抑制 Th2 细胞分化。
J Immunol Res. 2021 May 14;2021:6696525. doi: 10.1155/2021/6696525. eCollection 2021.
5
Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis.变应性鼻炎中的紧密连接和鼻上皮屏障完整性
PeerJ. 2020 Sep 4;8:e9834. doi: 10.7717/peerj.9834. eCollection 2020.
6
IL-37 relieves allergic inflammation by inhibiting the CCL11 signaling pathway in a mouse model of allergic rhinitis.在变应性鼻炎小鼠模型中，白细胞介素-37通过抑制CCL11信号通路减轻变应性炎症。
Exp Ther Med. 2020 Oct;20(4):3114-3121. doi: 10.3892/etm.2020.9078. Epub 2020 Jul 29.
7
Changes of CD4(+) CD25(+) Regulatory T Cells, FoxP3 in Adjuvant Arthritis Rats with Damage of Pulmonary Function and Effects of Tripterygium Glycosides Tablet.佐剂性关节炎大鼠肺功能损伤时CD4(+)CD25(+)调节性T细胞、FoxP3的变化及雷公藤多苷片的影响
Int J Rheumatol. 2012;2012:348450. doi: 10.1155/2012/348450. Epub 2012 Dec 27.
Ann Allergy Asthma Immunol. 2008 Apr;100(4):343-50. doi: 10.1016/S1081-1206(10)60597-2.
4
Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa.草花粉免疫疗法可诱导鼻黏膜中表达Foxp3的CD4+ CD25+细胞产生。
J Allergy Clin Immunol. 2008 Jun;121(6):1467-72, 1472.e1. doi: 10.1016/j.jaci.2008.03.013. Epub 2008 Apr 18.
5
GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.由GATA3驱动的Th2反应会抑制转化生长因子β1（TGF-β1）诱导的叉头盒蛋白P3（FOXP3）表达以及调节性T细胞的形成。
PLoS Biol. 2007 Dec;5(12):e329. doi: 10.1371/journal.pbio.0050329.
6
Effects of pollen and nasal glucocorticoid on FOXP3+, GATA-3+ and T-bet+ cells in allergic rhinitis.花粉和鼻用糖皮质激素对变应性鼻炎中FOXP3 +、GATA - 3 +和T - bet +细胞的影响。
Allergy. 2007 Sep;62(9):1007-13. doi: 10.1111/j.1398-9995.2007.01420.x.
7
Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation.舌下免疫疗法可诱导产生白细胞介素-10的调节性T细胞、过敏原特异性T细胞耐受及免疫偏移。
J Allergy Clin Immunol. 2007 Sep;120(3):707-13. doi: 10.1016/j.jaci.2007.06.013. Epub 2007 Aug 6.
8
Circulating Foxp3+CD4+ cell numbers in atopic patients and healthy control subjects.特应性患者和健康对照受试者体内循环的Foxp3 + CD4 +细胞数量。
J Allergy Clin Immunol. 2007 Oct;120(4):960-2. doi: 10.1016/j.jaci.2007.05.036. Epub 2007 Jul 12.
9
Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals.在非特应性个体和特应性个体中均证实存在循环的过敏原特异性CD4+CD25高表达Foxp3+调节性T细胞。
J Allergy Clin Immunol. 2007 Aug;120(2):429-36. doi: 10.1016/j.jaci.2007.05.002. Epub 2007 Jul 2.
10
A possible role of CD4+CD25+ T cells as well as transcription factor Foxp3 in the dysregulation of allergic rhinitis.CD4+CD25+ T细胞以及转录因子Foxp3在变应性鼻炎失调中的可能作用。
Laryngoscope. 2007 May;117(5):876-80. doi: 10.1097/MLG.0b013e318033f99a.