Kotake Shigeru, Yago Toru, Kawamoto Manabu, Nanke Yuki
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku, Tokyo 162-0054, Japan.
J Biomed Biotechnol. 2012;2012:675317. doi: 10.1155/2012/675317. Epub 2011 Nov 24.
Synovial tissues of patients with rheumatoid arthritis (RA) include factors regulating bone resorption, such as receptor activator NF-κB ligand (RANKL), TNF-α, IL-6, IL-17, and IFN-γ. However, in addition to these cytokines, other factors expressed in synovial tissues may play a role in regulating bone resorption. In 2009, we demonstrated that novel peptides from T-cell leukemia translocation-associated gene (TCTA) protein expressed in synovial tissues from patients with RA inhibit human osteoclastogenesis, preventing cellular fusion via the interaction between TCTA protein and a putative counterpart molecule. Only a few studies on the role of TCTA protein have been reported. Genomic Southern blots demonstrated a reduced TCTA signal in three of four small cell lung cancer cell lines, suggesting the loss of one of the two copies of the gene. In the current paper, we reviewed the roles of TCTA protein in lung cancer cell lines and human osteoclastogenesis.
类风湿性关节炎（RA）患者的滑膜组织包含调节骨吸收的因子，如核因子κB受体活化因子配体（RANKL）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-17（IL-17）和干扰素-γ（IFN-γ）。然而，除了这些细胞因子外，滑膜组织中表达的其他因子可能在调节骨吸收中发挥作用。2009年，我们证明类风湿性关节炎患者滑膜组织中表达的T细胞白血病易位相关基因（TCTA）蛋白的新型肽可抑制人破骨细胞生成，通过TCTA蛋白与假定的对应分子之间的相互作用阻止细胞融合。关于TCTA蛋白作用的研究报道较少。基因组Southern印迹显示，在四种小细胞肺癌细胞系中的三种中TCTA信号减弱，提示该基因的两个拷贝之一缺失。在本文中，我们综述了TCTA蛋白在肺癌细胞系和人破骨细胞生成中的作用。
