Predictors of hospital outcome without antidepressants in major depression.

Fifty-two consecutive inpatients with nonpsychotic unipolar major depression were assessed for response to 1 week of hospitalization without antidepressants. Each was rated at admission and at 1 week using the Hamilton Rating Scale for Depression (HRSD). Fifteen of 52 responded (HRSD score less than or equal to 12), 10 of whom improved by greater than or equal to 50% change in the HRSD score. Five variables were correlated with lack of hospital response: DSM-III melancholia, panic disorder, the DSM-III-R item "absence of personality disorder," admission severity, and age. Multiple regression showed an independent association between hospital outcome and the first three variables. Response to 1 week of hospitalization was found in 70% (14 of 20) of the patients who had none of the three identified predictors: melancholia, panic, and absence of personality disorder. In patients with one or more of these predictors, only 3% (1 of 32) responded.