肝癌肝切除术后的预后因素：来自中国的单中心经验。
Prognostic factors after liver resection for hepatocellular carcinoma: a single-center experience from China.
机构信息
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China.
出版信息
Am J Surg. 2012 Jun;203(6):741-50. doi: 10.1016/j.amjsurg.2011.05.010. Epub 2011 Dec 15.
BACKGROUND
This study aimed to clarify the risk factors for survival and recurrence of hepatocellular carcinoma (HCC) in a cohort of Chinese HCC patients after hepatectomy and to compare 6 developed staging systems.
METHODS
A retrospective analysis was performed on 165 consecutive patients. The Kaplan-Meier method was used to calculate survival. Postoperative prognostic factors were evaluated using univariate and multivariate analyses. The overall predictive power of each staging system was evaluated by the area under the receiver operating characteristic curve.
RESULTS
The overall survival rates of 1, 3, and 5 years were 81.2%, 58.6%, and 56.7%, respectively, and the corresponding disease-free survival rates were 52.9%, 23.3%, and 15.5%, respectively. α-fetoprotein level and blood transfusion were correlated significantly with patients' overall survival, and portal vein thrombosis and tumor size (>5 cm) were correlated significantly with poor disease-free survival.
CONCLUSIONS
The French staging system is better for predicting the prognosis of HCC patients receiving surgical treatment.
背景
本研究旨在明确中国肝癌患者接受肝切除术后生存和复发的危险因素，并比较 6 种已开发的分期系统。
方法
对 165 例连续患者进行回顾性分析。采用 Kaplan-Meier 法计算生存率。使用单因素和多因素分析评估术后预后因素。通过受试者工作特征曲线下面积评估每个分期系统的总体预测能力。
结果
1、3、5 年总生存率分别为 81.2%、58.6%和 56.7%，相应的无病生存率分别为 52.9%、23.3%和 15.5%。甲胎蛋白水平和输血与患者的总生存显著相关，门静脉血栓形成和肿瘤大小（>5 cm）与无病生存不良显著相关。
结论
法国分期系统更能预测接受手术治疗的 HCC 患者的预后。
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