帕金森病失用症的简短有效评估。
Short and valid assessment of apraxia in Parkinson's disease.
机构信息
Perception and Eye Movement Laboratory, Department of Neurology, Inselspital, University Hospital Bern, Switzerland.
出版信息
Parkinsonism Relat Disord. 2012 May;18(4):348-50. doi: 10.1016/j.parkreldis.2011.11.023. Epub 2011 Dec 16.
BACKGROUND
Valid assessment of apraxia in usually non-apraxic Parkinson's disease helps to delineate atypical parkinsonism frequently associated with apraxia. Furthermore, in a subgroup of late Parkinson's disease apraxia, typically the ideomotor subtype, may gradually superimpose onto parkinsonian motor symptoms contributing to defective manual skill. Here we evaluate the utility of a brief, standardized test, the apraxia screen of TULIA (AST).
METHODS
Seventy five Parkinson's disease patients were tested with the AST. Parkinsonian motor deficits were measured using Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III and difficulties in activities of daily living (ADL) by modified MDS-UPDRS part II (eating, dressing, personal hygiene, and writing).
RESULTS
No association was found between the AST and MDS-UPDRS part III, indicating that AST discriminates well (discriminative validity) between apraxia and parkinsonism. Furthermore, AST was associated with ADL and Hoehn & Yahr stage (convergent validity).
CONCLUSIONS
AST is a short and valid test to rule out or detect apraxia in Parkinson's disease.
背景
对通常非运动不能症的帕金森病患者进行失用症的有效评估有助于区分常伴有失用症的不典型帕金森综合征。此外，在帕金森病失用症的亚组中，通常是意念运动性失用症，可能会逐渐叠加到帕金森运动症状上，导致手部技能缺陷。在这里，我们评估了一种简短的标准化测试，即 TULIA 失用症筛查（AST）的效用。
方法
对 75 名帕金森病患者进行 AST 测试。使用运动障碍学会统一帕金森病评定量表（MDS-UPDRS）第三部分测量帕金森病运动缺陷，使用改良 MDS-UPDRS 第二部分（进食、穿衣、个人卫生和书写）测量日常生活活动（ADL）困难。
结果
AST 与 MDS-UPDRS 第三部分之间没有关联，这表明 AST 很好地区分了失用症和帕金森病（判别效度）。此外，AST 与 ADL 和 Hoehn & Yahr 分期相关（聚合效度）。
结论
AST 是一种简短且有效的测试，可以排除或检测帕金森病患者的失用症。
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