Translocation properties of copolymer (A(n)B(m))(l) through an interacting pore.

The translocation of a copolymer (A(n)B(m))(l) through an interacting pore was investigated by Monte Carlo simulation on a three-dimensional cubic lattice. Interactions between monomer A and pore ɛ(A) and between monomer B and pore ɛ(B) were considered. The difference between two translocation orientations, orientation A with monomer A entering the pore first and orientation B with monomer B first, was studied. Both the orientation probability and translocation time are dependent on monomer-pore interactions, block length, and fractions of monomers. The separation of different copolymers using translocation was also discussed. The results were explained qualitatively from the view of the free energy landscape of the copolymer translocation.