Department of Global Health, University of Washington, Seattle, WA 98104, USA.
Sex Transm Dis. 2012 Jan;39(1):21-4. doi: 10.1097/OLQ.0b013e31823b50c6.
In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405).
在一项针对非洲复发性生殖器疱疹女性的随机试验中,与安慰剂相比,间歇性阿昔洛韦治疗可适度增加病变愈合的可能性(风险比 [HR] = 1.48,P = 0.098;平均,5.1 天 vs. 6.0 天)和停止单纯疱疹病毒脱落(HR = 1.88,P = 0.008;平均,3.0 天 vs. 5.0 天),与高收入国家的研究结果相似(ClinicalTrials.gov 注册 NCT00808405)。