Xu Haiquan, Hu Xiaoqi, Zhang Qian, Du Songming, Fang Hongyun, Li Ying, Ma Jun, Li Tingyu, Du Lin, Guo Hongwei, Xu Guifa, Liu Ailing
National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Int J Hypertens. 2011;2011:987159. doi: 10.4061/2011/987159. Epub 2011 Dec 1.
A total of 8898 Chinese children (4580 boys and 4318 girls) aged 7-13 years in 6 cities of east China were recruited. Data on height, weight, waist circumference, blood pressure, serum lipid profiles, glucose, and insulin were collected. The overall prevalence of hypertension was 11.1%. Overweight and obese children had a higher risk of developing hypertension than their counterparts (29.1%, 17.4%, and 7.8%, resp.) (P = 0.0001). The means levels of triglycerides, glucose, insulin, and HOMA-IR (1.0 mmol/L, 4.5 mmol/L, 8.4 mU/mL and 1.7, resp.) among hypertensive children were all significantly higher than their normotensive counterparts (0.8 mmol/L, 4.5 mmol/L, 5.9 mU/mL, and 1.2, resp.) (P = 0.0001). Compared with the healthy children, the risk (odds ratio, OR) of having hypertension among children with high triglycerides, hyperglycemia, and metabolic syndrome was 1.4 (95% confidence interval (CI): 1.0-2.0, P = 0.0334), 1.5 (95% CI: 0.9-2.5, P = 0.0890), and 2.8 (95%CI: 1.5-5.4, P = 0.0014), respectively, after controlling for age, gender, BMI, income level, parents' education level and puberty. In conclusion, overweight and obese children have higher risk of having hypertension and children with dyslipidemia, hyperglycemia, and metabolic syndrome and higher HOMA-IR have higher risk of developing hypertension.
在中国东部6个城市招募了8898名7至13岁的中国儿童（4580名男孩和4318名女孩）。收集了身高、体重、腰围、血压、血脂谱、血糖和胰岛素的数据。高血压的总体患病率为11.1%。超重和肥胖儿童患高血压的风险高于正常儿童（分别为29.1%、17.4%和7.8%）（P = 0.0001）。高血压儿童的甘油三酯、血糖、胰岛素和HOMA-IR平均水平（分别为1.0 mmol/L、4.5 mmol/L、8.4 mU/mL和1.7）均显著高于血压正常的儿童（分别为0.8 mmol/L、4.5 mmol/L、5.9 mU/mL和1.2）（P = 0.0001）。在控制年龄、性别、BMI、收入水平、父母教育水平和青春期后，与健康儿童相比，高甘油三酯、高血糖和代谢综合征儿童患高血压的风险（比值比，OR）分别为1.4（95%置信区间（CI）：1.0 - 2.0，P = 0.0334）、1.5（95%CI：0.9 - 2.5，P = 0.0890）和2.8（95%CI：1.5 - 5.4，P = 0.0014）。总之，超重和肥胖儿童患高血压的风险更高，血脂异常、高血糖、代谢综合征以及HOMA-IR较高的儿童患高血压的风险更高。
