肺炎球菌性脑膜炎后大鼠脑中的乙酰胆碱酯酶活性。

Acetylcholinesterase activity in the rat brain after pneumococcal meningitis.

机构信息

Laboratory of Experimental Microbiology and National Institute of Science and Translacional Technology in Medicine, 88806-000 Criciúma, SC, Brazil.

出版信息

Microbiol Immunol. 2012 Mar;56(3):191-4. doi: 10.1111/j.1348-0421.2011.00418.x.

DOI:10.1111/j.1348-0421.2011.00418.x

PMID:22188584

Abstract

Pneumococcal meningitis is a life-threatening disease characterized by acute purulent infection of the meninges causing neuronal injury, cortical necrosis and hippocampal apoptosis. Cholinergic neurons and their projections are extensively distributed throughout the central nervous system. The aim of this study was to assess acetylcholinesterase activity in the rat brain after pneumococcal meningitis. In the hippocampus, frontal cortex and cerebrospinal fluid, acetylcholinesterase activity was found to be increased at 6, 12, 24, 48 and 96 hr without antibiotic treatment, and at 48 and 96 hr with antibiotic treatment. Our data suggest that acetylcholinesterase activity could be related to neuronal damage induced by pneumococcal meningitis.

摘要

肺炎球菌性脑膜炎是一种危及生命的疾病，其特征为脑膜的急性化脓性感染导致神经元损伤、皮质坏死和海马细胞凋亡。胆碱能神经元及其投射广泛分布于中枢神经系统。本研究旨在评估肺炎球菌性脑膜炎后大鼠大脑中的乙酰胆碱酯酶活性。在未接受抗生素治疗的情况下，在 6、12、24、48 和 96 小时时，在海马体、额叶皮质和脑脊液中发现乙酰胆碱酯酶活性增加，在接受抗生素治疗的情况下，在 48 和 96 小时时也发现乙酰胆碱酯酶活性增加。我们的数据表明，乙酰胆碱酯酶活性可能与肺炎球菌性脑膜炎引起的神经元损伤有关。