Digestive Endoscopy Center, Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
J Dig Dis. 2012 Jan;13(1):19-23. doi: 10.1111/j.1751-2980.2011.00548.x.
To study the clinical presentation, endoscopic features and prognosis of patients with synchronous upper gastrointestinal (GI) cancers.
A prospective database review of consecutive patients with synchronous upper GI malignancies was performed in a tertiary university hospital endoscopy unit. Gender, age, symptoms and cancer sites, endoscopic and pathological findings, as well as the long-term survival of these patients were analyzed.
A total of 64 patients with a median age of 56 years were included, in which 81.3% were male, 71.9% presented with notable features, 68.8% had familial history of cancer, 56.3% of gastric cancers were at the gastric body, 92.9% of the duodenal malignancies at the duodenal bulb, all esophageal cancers at the middle and lower part of esophagus and a significant proportion of tumors in the synchronous malignancies group were poorly differentiated. In all patients, 20 underwent curative surgical treatment and the 5-year survival rate was only 20%.
Patients with synchronous upper GI cancers are mainly male and present with different anatomic distribution and endoscopic features. They carry a poor prognosis as compared with single primary cancer patients. This case series describes the clinical profiles and emphasizes the necessity of a thorough examination for additional cancers before treatment of upper GI cancer.
研究同时性上消化道（GI）癌症患者的临床表现、内镜特征和预后。
在一家三级大学医院内镜科对连续的同时性上消化道恶性肿瘤患者进行前瞻性数据库回顾。分析这些患者的性别、年龄、症状和癌症部位、内镜和病理发现以及长期生存情况。
共纳入 64 例中位年龄为 56 岁的患者，其中 81.3%为男性，71.9%有明显特征，68.8%有癌症家族史，56.3%的胃癌发生在胃体，92.9%的十二指肠恶性肿瘤发生在十二指肠球部，所有食管癌均发生在食管中下段，且同步恶性肿瘤组的肿瘤有相当大比例分化不良。所有患者中，20 例行根治性手术治疗，5 年生存率仅为 20%。
同时性上消化道癌症患者主要为男性，具有不同的解剖分布和内镜特征。与单发性原发性癌症患者相比，他们的预后较差。本病例系列描述了临床特征，并强调在上消化道癌症治疗前对其他癌症进行彻底检查的必要性。
