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From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.
Biochem Pharmacol. 2011 Jul 1;82(1):9-16. doi: 10.1016/j.bcp.2011.03.011. Epub 2011 Mar 21.
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Contributions of the Ah receptor to bilirubin homeostasis and its antioxidative and atheroprotective functions.
Biol Chem. 2010 Jun;391(6):645-53. doi: 10.1515/BC.2010.065.
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Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.
Drug Metab Dispos. 2009 Sep;37(9):1978-86. doi: 10.1124/dmd.109.027409. Epub 2009 Jun 18.
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Introducing the "TCDD-inducible AhR-Nrf2 gene battery".
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Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial.
Cancer Prev Res (Phila). 2009 Apr;2(4):345-52. doi: 10.1158/1940-6207.CAPR-08-0178. Epub 2009 Mar 31.
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Bilirubin and glutathione have complementary antioxidant and cytoprotective roles.
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5171-6. doi: 10.1073/pnas.0813132106. Epub 2009 Mar 13.
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Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter.
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The search for endogenous activators of the aryl hydrocarbon receptor.
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