发育与疾病中的c-Rel转录因子
The c-Rel Transcription Factor in Development and Disease.
作者信息
Gilmore Thomas D, Gerondakis Steve
机构信息
Boston University, Biology Department, Boston, MA, USA.
出版信息
Genes Cancer. 2011 Jul;2(7):695-711. doi: 10.1177/1947601911421925.
Abstract
c-Rel is a member of the nuclear factor κB (NF-κB) transcription factor family. Unlike other NF-κB proteins that are expressed in a variety of cell types, high levels of c-Rel expression are found primarily in B and T cells, with many c-Rel target genes involved in lymphoid cell growth and survival. In addition to c-Rel playing a major role in mammalian B and T cell function, the human c-rel gene (REL) is a susceptibility locus for certain autoimmune diseases such as arthritis, psoriasis, and celiac disease. The REL locus is also frequently altered (amplified, mutated, rearranged), and expression of REL is increased in a variety of B and T cell malignancies and, to a lesser extent, in other cancer types. Thus, agents that modulate REL activity may have therapeutic benefits for certain human cancers and chronic inflammatory diseases.
摘要
c-Rel是核因子κB（NF-κB）转录因子家族的成员。与在多种细胞类型中表达的其他NF-κB蛋白不同，c-Rel的高表达主要见于B细胞和T细胞，许多c-Rel靶基因参与淋巴细胞的生长和存活。除了c-Rel在哺乳动物B细胞和T细胞功能中起主要作用外，人类c-rel基因（REL）是某些自身免疫性疾病（如关节炎、银屑病和乳糜泻）的易感基因座。REL基因座也经常发生改变（扩增、突变、重排），并且REL的表达在多种B细胞和T细胞恶性肿瘤中增加，在其他癌症类型中增加程度较小。因此，调节REL活性的药物可能对某些人类癌症和慢性炎症性疾病具有治疗益处。
相似文献
1
The c-Rel Transcription Factor in Development and Disease.
Genes Cancer. 2011 Jul;2(7):695-711. doi: 10.1177/1947601911421925.
2
The c-Rel transcription factor and B-cell proliferation: a deal with the devil.
Oncogene. 2004 Mar 25;23(13):2275-86. doi: 10.1038/sj.onc.1207410.
3
Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel.
J Immunol. 2007 Jun 1;178(11):7097-109. doi: 10.4049/jimmunol.178.11.7097.
4
The NF-kappaB signalling pathway: a therapeutic target in lymphoid malignancies?
Expert Opin Ther Targets. 2005 Oct;9(5):1045-61. doi: 10.1517/14728222.9.5.1045.
5
Aberrant rel/nfkb genes and activity in human cancer.
Oncogene. 1999 Nov 22;18(49):6938-47. doi: 10.1038/sj.onc.1203221.
6
Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity.
J Leukoc Biol. 2002 Nov;72(5):1054-62.
7
Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel.
J Immunol. 2010 Aug 15;185(4):2350-9. doi: 10.4049/jimmunol.1000317. Epub 2010 Jul 16.
8
RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo.
PLoS One. 2009;4(4):e5028. doi: 10.1371/journal.pone.0005028. Epub 2009 Apr 6.
9
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.
J Clin Invest. 1997 Dec 15;100(12):2952-60. doi: 10.1172/JCI119848.
10
The c-Rel-c-Myc axis controls metabolism and proliferation of human T leukemia cells.
Mol Immunol. 2020 Sep;125:115-122. doi: 10.1016/j.molimm.2020.06.029. Epub 2020 Jul 10.
引用本文的文献
1
MALAT1 Expression Is Deregulated in miR-34a Knockout Cell Lines.
Noncoding RNA. 2025 Aug 5;11(4):60. doi: 10.3390/ncrna11040060.
2
Systemic Sclerosis with Interstitial Lung Disease: Identification of Novel Immunogenetic Markers and Ethnic Specificity in Kazakh Patients.
Epidemiologia (Basel). 2025 Aug 6;6(3):41. doi: 10.3390/epidemiologia6030041.
3
Stepwise neofunctionalization of the NF-κB family member Rel during vertebrate evolution.
Nat Immunol. 2025 May;26(5):760-774. doi: 10.1038/s41590-025-02138-2. Epub 2025 Apr 30.
4
HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses.
iScience. 2024 Dec 30;28(2):111710. doi: 10.1016/j.isci.2024.111710. eCollection 2025 Feb 21.
5
Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache.
Brain. 2025 Jan 17. doi: 10.1093/brain/awaf015.
6
Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease.
J Crohns Colitis. 2025 Jan 11;19(1). doi: 10.1093/ecco-jcc/jjae191.
7
NF-κB c-Rel is a critical regulator of TLR7-induced inflammation in psoriasis.
EBioMedicine. 2024 Dec;110:105452. doi: 10.1016/j.ebiom.2024.105452. Epub 2024 Nov 24.
8
Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution.
Sci Transl Med. 2024 Nov 13;16(773):eadr1032. doi: 10.1126/scitranslmed.adr1032.
9
NF-κB Transcription Factors: Their Distribution, Family Expansion, Structural Conservation, and Evolution in Animals.
Int J Mol Sci. 2024 Sep 10;25(18):9793. doi: 10.3390/ijms25189793.
10
Unraveling the interplay of neuroinflammatory signaling between parenchymal and meningeal cells in migraine headache.
J Headache Pain. 2024 Jul 31;25(1):124. doi: 10.1186/s10194-024-01827-x.
本文引用的文献
1
Potential celiac patients: a model of celiac disease pathogenesis.
PLoS One. 2011;6(7):e21281. doi: 10.1371/journal.pone.0021281. Epub 2011 Jul 8.
2
The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death.
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12030-5. doi: 10.1073/pnas.1101450108. Epub 2011 Jul 5.
3
ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.
Cancer Res. 2011 May 15;71(10):3688-700. doi: 10.1158/0008-5472.CAN-10-3445.
4
Clinicopathologic significances of nuclear expression of nuclear factor-κB transcription factors in retinoblastoma.
J Clin Pathol. 2011 Aug;64(8):695-700. doi: 10.1136/jclinpath-2011-200017. Epub 2011 May 7.
5
Recent insights into the genetics of inflammatory bowel disease.
Gastroenterology. 2011 May;140(6):1704-12. doi: 10.1053/j.gastro.2011.02.046.
6
Foxp3 interacts with c-Rel to mediate NF-κB repression.
PLoS One. 2011 Apr 7;6(4):e18670. doi: 10.1371/journal.pone.0018670.
7
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.
Hepatology. 2011 Jun;53(6):1977-85. doi: 10.1002/hep.24307. Epub 2011 May 2.
8
JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation.
Biochem Biophys Res Commun. 2011 Apr 1;407(1):141-7. doi: 10.1016/j.bbrc.2011.02.126. Epub 2011 Mar 1.
9
Critical role of cRel subunit of NF-κB in sepsis survival.
Infect Immun. 2011 May;79(5):1848-54. doi: 10.1128/IAI.00021-11. Epub 2011 Feb 22.
10
Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 May;111(5):594-607. doi: 10.1016/j.tripleo.2010.11.020. Epub 2011 Feb 22.
Zotero 插件