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[影响贲门癌切除术后生存的因素。全食管胃切除术与上极食管胃切除术的比较]

[Factors influencing survival after resection of cancer of the cardia. Comparison of total esophagogastrectomy and upper pole esophagogastrectomy].

作者信息

Bernard A, Obadia J F, Arnould H, Cougard P, Viard H

机构信息

Clinique Chirurgicale, Hôpital du Bocage, Dijon.

出版信息

Ann Chir. 1990;44(6):459-63.

PMID:2221792
Abstract

Total oesophagogastrectomy (TOG) is the best surgical technique for carcinoma of the cardia. However, oesophagogastric anastomosis is easier in upper pole oesophagogastrectomy (UPOG). This is a retrospective study excluding post-operative deaths and palliative surgery. We studied the factors affecting the survival and then compared TOG (n = 15) and UPOG (n = 26) in carcinomas of the cardia. Bad prognosis was related to several factors: poorly differentiated adenocarcinomas, tumor size, lymph node involvement and residual tumor at the resection margins. The survival rate of resected carcinomas of the cardia was 22 +/- 13%. No difference was noted between extended and limited resections. 5-year survival after UPOG was 20 + 18% and after TOG 11% (0-30) (p = 0.21). In stage 1B, 5-year survival after UPOG 11% and TOG was 50% (19-81) and 33% (0-82) (p = 0.54). In stages II and III A, 3-year survival after UPOG and TOG was 7% (0-20) and 0% (p = 0.16). For a given tumor size, 5-year survival is the same whatever the technique.

摘要

全食管胃切除术(TOG)是治疗贲门癌的最佳手术技术。然而,在食管胃上极切除术(UPOG)中,食管胃吻合术更容易。这是一项回顾性研究,排除了术后死亡病例和姑息性手术。我们研究了影响生存的因素,然后比较了TOG组(n = 15)和UPOG组(n = 26)的贲门癌患者情况。预后不良与几个因素有关:低分化腺癌、肿瘤大小、淋巴结受累情况以及手术切缘的残留肿瘤。贲门癌切除术后的生存率为22±13%。扩大切除和有限切除之间未发现差异。UPOG术后5年生存率为20 + 18%,TOG术后为11%(0 - 30)(p = 0.21)。在1B期,UPOG术后5年生存率为11%,TOG术后为50%(19 - 81)和33%(0 - 82)(p = 0.54)。在II期和IIIA期,UPOG和TOG术后3年生存率分别为7%(0 - 20)和0%(p = 0.16)。对于给定的肿瘤大小,无论采用何种技术,5年生存率相同。

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