Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
J Acquir Immune Defic Syndr. 2012 Feb 1;59(2):121-5. doi: 10.1097/QAI.0b013e3182392ebe.
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
研究了炎症小体基因在 HIV-1 感染易感性中的作用。在 150 名 HIV-1 感染的巴西受试者和 158 名健康对照中，分析了 NLRP1、NLRP3、NLRC4、CARD8、CASP1 和 IL1B 基因内的 12 个单核苷酸多态性。NLRP3 中的 rs10754558 和 IL1B 中的 rs1143634 这 2 个多态性与 HIV-1 感染显著相关。这些发现支持了 NALP3-炎症小体在 HIV-1 发病机制中的先前假设，再次强调了炎症和先天免疫在 HIV-1 感染易感性中的关键作用。
