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复方磺胺甲噁唑预防与侵袭性肺炎球菌病的抗生素耐药性。

Trimethoprim-sulfamethoxazole prophylaxis and antibiotic nonsusceptibility in invasive pneumococcal disease.

机构信息

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

出版信息

Antimicrob Agents Chemother. 2012 Mar;56(3):1602-5. doi: 10.1128/AAC.05813-11. Epub 2012 Jan 9.

DOI:10.1128/AAC.05813-11
PMID:22232291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3294938/
Abstract

Among 5,043 invasive pneumococcal disease (IPD) isolates identified through South African national surveillance from 2003 to 2007, we estimated the effect of trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis on antimicrobial resistance. Patients on TMP-SMX prophylaxis were more likely to have a pneumococcal isolate nonsusceptible to TMP-SMX, penicillin, and rifampin. TMP-SMX nonsusceptibility was associated with nonsusceptibility to penicillin, erythromycin, and rifampin and multidrug resistance. This study informs empirical treatment of suspected IPD in patients with a history of TMP-SMX use.

摘要

在南非国家监测系统 2003 至 2007 年间所确定的 5043 例侵袭性肺炎球菌病（IPD）分离株中，我们评估了复方磺胺甲噁唑（TMP-SMX）预防对药物耐药性的影响。接受 TMP-SMX 预防的患者其肺炎球菌分离株对 TMP-SMX、青霉素和利福平的耐药性更可能增加。TMP-SMX 耐药与青霉素、红霉素和利福平耐药以及耐多药有关。本研究为 TMP-SMX 使用史患者疑似 IPD 的经验性治疗提供了信息。

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